The DNA Replication Stress Hypothesis of Alzheimer’s Disease
Joint Authors
Iourov, Ivan Y.
Vorsanova, Svetlana G.
Yurov, Yuri B.
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-01-02
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
A well-recognized theory of Alzheimer’s disease (AD) pathogenesis suggests ectopic cell cycle events to mediate neurodegeneration.
Vulnerable neurons of the AD brain exhibit biomarkers of cell cycle progression and DNA replication suggesting a reentry into the cell cycle.
Chromosome reduplication without proper cell cycle completion and mitotic division probably causes neuronal cell dysfunction and death.
However, this theory seems to require some inputs in accordance with the generally recognized amyloid cascade theory as well as to explain causes and consequences of genomic instability (aneuploidy) in the AD brain.
We propose that unscheduled and incomplete DNA replication (replication stress) destabilizes (epi)genomic landscape in the brain and leads to DNA replication “catastrophe” causing cell death during the S phase (replicative cell death).
DNA replication stress can be a key element of the pathogenetic cascade explaining the interplay between ectopic cell cycle events and genetic instabilities in the AD brain.
Abnormal cell cycle reentry and somatic genome variations can be used for updating the cell cycle theory introducing replication stress as a missing link between cell genetics and neurobiology of AD.
American Psychological Association (APA)
Yurov, Yuri B.& Vorsanova, Svetlana G.& Iourov, Ivan Y.. 2012. The DNA Replication Stress Hypothesis of Alzheimer’s Disease. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-1027885
Modern Language Association (MLA)
Vorsanova, Svetlana G.…[et al.]. The DNA Replication Stress Hypothesis of Alzheimer’s Disease. The Scientific World Journal No. 2011 (2011), pp.1-11.
https://search.emarefa.net/detail/BIM-1027885
American Medical Association (AMA)
Yurov, Yuri B.& Vorsanova, Svetlana G.& Iourov, Ivan Y.. The DNA Replication Stress Hypothesis of Alzheimer’s Disease. The Scientific World Journal. 2012. Vol. 2011, no. 2011, pp.1-11.
https://search.emarefa.net/detail/BIM-1027885
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027885