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Pro- and Antiapoptotic Markers in Upper Tract Urothelial CarcinomaAssociated with Balkan Endemic Nephropathy
Joint Authors
Jankovic-Velickovic, Ljubinka
Stojnev, Slavica
Ristic-Petrovic, Ana
Dolicanin, Zana
Hattori, Takanori
Mukaisho, Kenichi
Stojanovic, Mariola
Stefanovic, Vladisav
Source
Issue
Vol. 2011, Issue 2011 (31 Dec. 2011), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-29
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Medicine
Information Technology and Computer Science
Abstract EN
The role of aristolochic acid in the etiology of Balkan endemic nephropathy (BEN) and associated upper-tract urothelial carcinoma (UTUC) has been recently confirmed.
The aim of this study was to determine apoptosis-related marker(s) specific for BEN-associated UTUC.
Present investigation included 105 patients with UTUC, 44 from BEN region and 61 control tumors.
Altered expression of Survivin was more often present in BEN UTUC with high grade and solid growth (P<0.005; P<0.05) than in control tumors.
Significantly lower expression of proapoptotic marker Bax was found in BEN tumors with high grade, high stage, necrosis, and without metaplastic change (P<0.05; 0.05; 0.05; 0.05) compared to control tumors with the same features.
Group (BEN-related/control), stage, growth pattern, and caspase 3 activity were significantly associated with the expression of Bax (P=0.002, 0.034, 0.047, 0.028, resp.,).
This investigation identifies Bax as specific marker of BEN-associated UTUC.
Decrease of pro-apoptotic protein Bax together with alteration of Survivin may be indicative for specific disturbances of intrinsic apoptotic pathway in UTUC arising in endemic areas.
American Psychological Association (APA)
Jankovic-Velickovic, Ljubinka& Stojnev, Slavica& Ristic-Petrovic, Ana& Dolicanin, Zana& Hattori, Takanori& Mukaisho, Kenichi…[et al.]. 2011. Pro- and Antiapoptotic Markers in Upper Tract Urothelial CarcinomaAssociated with Balkan Endemic Nephropathy. The Scientific World Journal،Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027892
Modern Language Association (MLA)
Jankovic-Velickovic, Ljubinka…[et al.]. Pro- and Antiapoptotic Markers in Upper Tract Urothelial CarcinomaAssociated with Balkan Endemic Nephropathy. The Scientific World Journal No. 2011 (2011), pp.1-12.
https://search.emarefa.net/detail/BIM-1027892
American Medical Association (AMA)
Jankovic-Velickovic, Ljubinka& Stojnev, Slavica& Ristic-Petrovic, Ana& Dolicanin, Zana& Hattori, Takanori& Mukaisho, Kenichi…[et al.]. Pro- and Antiapoptotic Markers in Upper Tract Urothelial CarcinomaAssociated with Balkan Endemic Nephropathy. The Scientific World Journal. 2011. Vol. 2011, no. 2011, pp.1-12.
https://search.emarefa.net/detail/BIM-1027892
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027892