Ustekinumab in Psoriasis Immunopathology with Emphasis on the Th17-IL23 Axis: A Primer
Joint Authors
Quatresooz, Pascale
Piérard, Gérald E.
Delvenne, Philippe
Hermanns-Lê, Trinh
Piérard-Franchimont, Claudine
Humbert, Philippe
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-5, 5 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-06-12
Country of Publication
Egypt
No. of Pages
5
Main Subjects
Abstract EN
Psoriasis is a chronic relapsing immunoinflammatory dermatosis that is commonly associated with systemic comorbidities.
The pathogenic importance of interleukin (IL)-12 and IL-23 is beyond doubt, as well as the involvement of T helper cells (Th)1 and Th17 cells.
There is upregulation of the p40 subunit shared by IL-12 and IL-23 and of the IL-23 p19 subunit, but not an increased expression of the IL-12 p35 subunit.
This indicates that IL-23 appears more involved than IL-12 in the pathogenesis of psoriatic plaques.
Ustekinumab is a fully human monoclonal antibody of the immunoglobulin (Ig) G1 class targeting the p40 subunit common to both IL-12 and IL-23, thus inhibiting both IL-12 and IL-23 receptor-mediated signalling.
Ustekinumab is part of the recent biologic therapies active in psoriasis, autoimmune arthritides, and inflammatory bowel diseases.
American Psychological Association (APA)
Quatresooz, Pascale& Hermanns-Lê, Trinh& Piérard, Gérald E.& Humbert, Philippe& Delvenne, Philippe& Piérard-Franchimont, Claudine. 2012. Ustekinumab in Psoriasis Immunopathology with Emphasis on the Th17-IL23 Axis: A Primer. BioMed Research International،Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1027904
Modern Language Association (MLA)
Quatresooz, Pascale…[et al.]. Ustekinumab in Psoriasis Immunopathology with Emphasis on the Th17-IL23 Axis: A Primer. BioMed Research International No. 2012 (2012), pp.1-5.
https://search.emarefa.net/detail/BIM-1027904
American Medical Association (AMA)
Quatresooz, Pascale& Hermanns-Lê, Trinh& Piérard, Gérald E.& Humbert, Philippe& Delvenne, Philippe& Piérard-Franchimont, Claudine. Ustekinumab in Psoriasis Immunopathology with Emphasis on the Th17-IL23 Axis: A Primer. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-5.
https://search.emarefa.net/detail/BIM-1027904
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027904