Transfer of Bone-Marrow-Derived Mesenchymal Stem Cells Influences Vascular Remodeling and Calcification after Balloon Injury in Hyperlipidemic Rats
Joint Authors
Chen, Xiaochun
Zou, Yunzeng
Ge, Junbo
Liao, Jianquan
Duan, Hongyu
Ge, Zhiping
Li, Yongdong
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-14
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Bone-marrow-derived mesenchymal stem cells (BM-MSCs) were found to markedly increase atherosclerotic lesion size.
The aim of this paper was to investigate whether BM-MSCs contribute to vascular remodeling and calcification after balloon injury in hyperlipidemic rats.
Labeled BM-MSCs were found in the lesion of hyperlipidemic rats after balloon injury.
Comparing injury group, transferred BM-MSCs significantly triggered vascular negative remodeling, characterized by the changes of remodeling index (0.628±0.0293 versus 0.544±0.0217), neointimal area (0.078±0.015 mm2 versus 0.098±0.019 mm2), PCNA index (23.91±6.59% versus 43.11±5.31%), and percentage of stenosis (18.20±1.09% versus 30.58±1.21%).
Apparent vascular calcification was detected in medial layers at 6 weeks after balloon angioplasty, which may be associated with upregulation of bone morphogenetic protein-2 (BMP-2).
Our data indicated that unselected BM-MSCs transfer may induce vascular remodeling and calcification after balloon injury in hyperlipidemic rats.
American Psychological Association (APA)
Liao, Jianquan& Chen, Xiaochun& Li, Yongdong& Ge, Zhiping& Duan, Hongyu& Zou, Yunzeng…[et al.]. 2012. Transfer of Bone-Marrow-Derived Mesenchymal Stem Cells Influences Vascular Remodeling and Calcification after Balloon Injury in Hyperlipidemic Rats. BioMed Research International،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1027905
Modern Language Association (MLA)
Liao, Jianquan…[et al.]. Transfer of Bone-Marrow-Derived Mesenchymal Stem Cells Influences Vascular Remodeling and Calcification after Balloon Injury in Hyperlipidemic Rats. BioMed Research International No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1027905
American Medical Association (AMA)
Liao, Jianquan& Chen, Xiaochun& Li, Yongdong& Ge, Zhiping& Duan, Hongyu& Zou, Yunzeng…[et al.]. Transfer of Bone-Marrow-Derived Mesenchymal Stem Cells Influences Vascular Remodeling and Calcification after Balloon Injury in Hyperlipidemic Rats. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1027905
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027905
