Usefulness of FDG, MET and FLT-PET Studies for the Management of Human Gliomas
Joint Authors
Miyake, Keisuke
Shinomiya, Aya
Hatakeyama, Tetsuhiro
Tamiya, Takashi
Kawai, Nobuyuki
Okada, Masaki
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
The use of positron imaging agents such as FDG, MET, and FLT is expected to lead the way for novel applications toward efficient malignancy grading and treatment of gliomas.
In this study, the usefulness of FDG, MET and FLT-PET images was retrospectively reviewed by comparing their histopathological findings.
FDG, MET, and FLT-PET were performed in 27 patients with WHO grade IV, 15 patients with WHO grade III, and 12 patients with WHO grade II during 5.5 years.
The resulting PET images were compared by measuring SUVs and T/N ratios (tumor to normal tissue ratios).
Although there were no significant differences in FDG-PET, there were significant differences in the T/N ratios in the MET-PET between WHO grades II and IV and in the FLT-PET between the WHO grades III and IV.
In glioblastoma patients, the SUVs of the areas depicted by MRI in the MET-PET were different from those SUVs in the FLT-PET.
Importantly, the areas with high SUVs in both MET-PET and FLT-PET were also high in Ki-67 index and were histologically highly malignant.
PET imaging is a noninvasive modality that is useful in determining a tumor area for removal as well as improving preoperative diagnosis for gliomas.
American Psychological Association (APA)
Miyake, Keisuke& Shinomiya, Aya& Okada, Masaki& Hatakeyama, Tetsuhiro& Kawai, Nobuyuki& Tamiya, Takashi. 2012. Usefulness of FDG, MET and FLT-PET Studies for the Management of Human Gliomas. BioMed Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1027907
Modern Language Association (MLA)
Miyake, Keisuke…[et al.]. Usefulness of FDG, MET and FLT-PET Studies for the Management of Human Gliomas. BioMed Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1027907
American Medical Association (AMA)
Miyake, Keisuke& Shinomiya, Aya& Okada, Masaki& Hatakeyama, Tetsuhiro& Kawai, Nobuyuki& Tamiya, Takashi. Usefulness of FDG, MET and FLT-PET Studies for the Management of Human Gliomas. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1027907
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027907