Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination
Joint Authors
McGinty, John
Benencia, Fabian
Pate, Michelle
Sprague, Leslee
Muccioli, Maria
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-15, 15 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-28
Country of Publication
Egypt
No. of Pages
15
Main Subjects
Abstract EN
Many clinical trials have been carried out or are in progress to assess the therapeutic potential of dendritic-cell- (DC-) based vaccines on cancer patients, and recently the first DC-based vaccine for human cancer was approved by the FDA.
Herewith, we describe the general characteristics of DCs and different strategies to generate effective antitumor DC vaccines.
In recent years, the relevance of the tumor microenvironment in the progression of cancer has been highlighted.
It has been shown that the tumor microenvironment is capable of inactivating various components of the immune system responsible for tumor clearance.
In particular, the effect of the tumor microenvironment on antigen-presenting cells, such as DCs, does not only render these immune cells unable to induce specific immune responses, but also turns them into promoters of tumor growth.
We also describe strategies likely to increase the efficacy of DC vaccines by reprogramming the immunosuppressive nature of the tumor microenvironment.
American Psychological Association (APA)
Benencia, Fabian& Sprague, Leslee& McGinty, John& Pate, Michelle& Muccioli, Maria. 2011. Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination. BioMed Research International،Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1027921
Modern Language Association (MLA)
Benencia, Fabian…[et al.]. Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination. BioMed Research International No. 2012 (2012), pp.1-15.
https://search.emarefa.net/detail/BIM-1027921
American Medical Association (AMA)
Benencia, Fabian& Sprague, Leslee& McGinty, John& Pate, Michelle& Muccioli, Maria. Dendritic Cells The Tumor Microenvironment and the Challenges for an Effective Antitumor Vaccination. BioMed Research International. 2011. Vol. 2012, no. 2012, pp.1-15.
https://search.emarefa.net/detail/BIM-1027921
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027921