Camel Milk Triggers Apoptotic Signaling Pathways in Human Hepatoma HepG2 and Breast Cancer MCF7 Cell Lines through Transcriptional Mechanism
Joint Authors
Alhaider, Abdulqader A.
Korashy, Hesham M.
El-Kadi, Ayman O. S.
Abd-Allah, Adel R.
Maayah, Zaid H.
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-13
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Few published studies have reported the use of crude camel milk in the treatment of stomach infections, tuberculosis and cancer.
Yet, little research was conducted on the effect of camel milk on the apoptosis and oxidative stress associated with human cancer.
The present study investigated the effect and the underlying mechanisms of camel milk on the proliferation of human cancer cells using an in vitro model of human hepatoma (HepG2) and human breast (MCF7) cancer cells.
Our results showed that camel milk, but not bovine milk, significantly inhibited HepG2 and MCF7 cells proliferation through the activation of caspase-3 mRNA and activity levels, and the induction of death receptors in both cell lines.
In addition, Camel milk enhanced the expression of oxidative stress markers, heme oxygenase-1 and reactive oxygen species production in both cells.
Mechanistically, the increase in caspase-3 mRNA levels by camel milk was completely blocked by the transcriptional inhibitor, actinomycin D; implying that camel milk increased de novo RNA synthesis.
Furthermore, Inhibition of the mitogen activated protein kinases differentially modulated the camel milk-induced caspase-3 mRNA levels.
Taken together, camel milk inhibited HepG2 and MCF7 cells survival and proliferation through the activation of both the extrinsic and intrinsic apoptotic pathways.
American Psychological Association (APA)
Korashy, Hesham M.& Maayah, Zaid H.& Abd-Allah, Adel R.& El-Kadi, Ayman O. S.& Alhaider, Abdulqader A.. 2012. Camel Milk Triggers Apoptotic Signaling Pathways in Human Hepatoma HepG2 and Breast Cancer MCF7 Cell Lines through Transcriptional Mechanism. BioMed Research International،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1027927
Modern Language Association (MLA)
Korashy, Hesham M.…[et al.]. Camel Milk Triggers Apoptotic Signaling Pathways in Human Hepatoma HepG2 and Breast Cancer MCF7 Cell Lines through Transcriptional Mechanism. BioMed Research International No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1027927
American Medical Association (AMA)
Korashy, Hesham M.& Maayah, Zaid H.& Abd-Allah, Adel R.& El-Kadi, Ayman O. S.& Alhaider, Abdulqader A.. Camel Milk Triggers Apoptotic Signaling Pathways in Human Hepatoma HepG2 and Breast Cancer MCF7 Cell Lines through Transcriptional Mechanism. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1027927
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027927