Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization
Joint Authors
Liu, Po-Len
Chen, Huey-Yi
Chen, Wen-Chi
Lin, Yi-Wen
Man, Kee-Ming
Wang, Hui-Min
Wang, Shu-Huei
Chen, Yuh-Lien
Liu, Jung-Tung
Yin, Wei-Hsian
Chen, Yung-Hsiang
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-08
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Pigment epithelium-derived factor (PEDF) was first identified in retinal pigment epithelium cells.
It is an endogenously produced protein that is widely expressed throughout the human body such as in the eyes, liver, heart, and adipose tissue; it exhibits multiple and varied biological activities.
PEDF is a multifunctional protein with antiangiogenic, antitumorigenic, antioxidant, anti-inflammatory, antithrombotic, neurotrophic, and neuroprotective properties.
More recently, PEDF has been shown to be the most potent inhibitor of stem/progenitor cell-associated neovascularization.
Neovascularization is a complex process regulated by a large, interacting network of molecules from stem/progenitor cells.
PEDF is also involved in the pathogenesis of angiogenic eye disease, tumor growth, and cardiovascular disease.
Novel antiangiogenic agents with tolerable side effects are desired for the treatment of patients with various diseases.
Here, we review the value of PEDF as an important endogenous antiangiogenic molecule; we focus on the recently identified role of PEDF as a possible new target molecule to influence stem/progenitor cell-related neovascularization.
American Psychological Association (APA)
Liu, Jung-Tung& Chen, Yuh-Lien& Chen, Wen-Chi& Chen, Huey-Yi& Lin, Yi-Wen& Wang, Shu-Huei…[et al.]. 2012. Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization. BioMed Research International،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1027939
Modern Language Association (MLA)
Liu, Jung-Tung…[et al.]. Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization. BioMed Research International No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1027939
American Medical Association (AMA)
Liu, Jung-Tung& Chen, Yuh-Lien& Chen, Wen-Chi& Chen, Huey-Yi& Lin, Yi-Wen& Wang, Shu-Huei…[et al.]. Role of Pigment Epithelium-Derived Factor in StemProgenitor Cell-Associated Neovascularization. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1027939
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027939