Xenogenic Esophagus Scaffolds Fixed with Several Agents: Comparative In Vivo Study of Rejection and Inflammation
Joint Authors
Till, Holger
Emmrich, Frank
Aupperle, Heike
Koch, Holger
Sack, Ulrich
Metzger, Roman
Graneist, Cora
Schierle, Katrin
Boldt, Andreas
Source
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Most infants with long-gap esophageal atresia receive an esophageal replacement with tissue from stomach or colon, because the native esophagus is too short for true primary repair.
Tissue-engineered esophageal conducts could present an attractive alternative.
In this paper, circular decellularized porcine esophageal scaffold tissues were implanted subcutaneously into Sprague-Dawley rats.
Depending on scaffold cross-linking with genipin, glutaraldehyde, and carbodiimide (untreated scaffolds : positive control; bovine pericardium : gold standard), the number of infiltrating fibroblasts, lymphocytes, macrophages, giant cells, and capillaries was determined to quantify the host response after 1, 9, and 30 days.
Decellularized esophagus scaffolds were shown to maintain native matrix morphology and extracellular matrix composition.
Typical inflammatory reactions were observed in all implants; however, the cellular infiltration was reduced in the genipin group.
We conclude that genipin is the most efficient and best tolerated cross-linking agent to attenuate inflammation and to improve the integration of esophageal scaffolds into its surrounding tissue after implantation.
American Psychological Association (APA)
Koch, Holger& Graneist, Cora& Emmrich, Frank& Till, Holger& Metzger, Roman& Aupperle, Heike…[et al.]. 2012. Xenogenic Esophagus Scaffolds Fixed with Several Agents: Comparative In Vivo Study of Rejection and Inflammation. BioMed Research International،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1027942
Modern Language Association (MLA)
Koch, Holger…[et al.]. Xenogenic Esophagus Scaffolds Fixed with Several Agents: Comparative In Vivo Study of Rejection and Inflammation. BioMed Research International No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1027942
American Medical Association (AMA)
Koch, Holger& Graneist, Cora& Emmrich, Frank& Till, Holger& Metzger, Roman& Aupperle, Heike…[et al.]. Xenogenic Esophagus Scaffolds Fixed with Several Agents: Comparative In Vivo Study of Rejection and Inflammation. BioMed Research International. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1027942
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027942