The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency
Joint Authors
Lu, Cheng
Zhao, Hongyan
Li, Jian
He, Xiaojuan
Ju, Dahong
Lu, Aiping
Niu, Xuyan
Zhao, Ning
Xiao, Cheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-05
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Androgens have been linked to the onset, severity, and progression of rheumatoid arthritis (RA).
In traditional Chinese medicine (TCM), the most common pattern in RA is kidney deficiency, which partly corresponds to a low sex hormone state.
In this study, TCM kidney deficiency was induced in male Sprague-Dawley rats with castration surgery, and a TCM preparation, Yi Shen Juan Bi Pill (YJB), was used to treat collagen induced arthritis (CIA) rats with castration.
Metabolomic technique was used to evaluate the pharmacological mechanism in castrated CIA rats treated by YJB.
The results showed that castration significantly increased the severity of the arthritis in rats but was ameliorated by YJB.
Its pharmacological mechanism was partially associated with lipid metabolites involving free fatty acid (FFA) and lysophosphatidylcholine (LPC).
In conclusion, the experimental results demonstrate the protective effect of YJB on the TCM kidney deficiency pattern induced by androgen deficiency in CIA rats and support that YJB should be used for the clinical treatment of RA with TCM kidney deficiency pattern.
American Psychological Association (APA)
Zhao, Hongyan& Li, Jian& He, Xiaojuan& Lu, Cheng& Xiao, Cheng& Niu, Xuyan…[et al.]. 2012. The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1027958
Modern Language Association (MLA)
Zhao, Hongyan…[et al.]. The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1027958
American Medical Association (AMA)
Zhao, Hongyan& Li, Jian& He, Xiaojuan& Lu, Cheng& Xiao, Cheng& Niu, Xuyan…[et al.]. The Protective Effect of Yi Shen Juan Bi Pill in Arthritic Rats with Castration-Induced Kidney Deficiency. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1027958
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027958