Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis
Joint Authors
Ikarashi, Nobutomo
Sato, Wataru
Toda, Takahiro
Ishii, Makoto
Sugiyama, Kiyoshi
Ochiai, Wataru
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
We examined the inhibitory effect of polyphenol-rich aqueous extract from the bark of Acacia mearnsii (PrA) on itching associated with atopic dermatitis (AD).
HR-1 mice were fed a normal diet, special diet (AD group), or special diet containing 3% PrA (PrA group) for 6 weeks.
In the AD group, itching frequency and transepidermal water loss increased compared to the control group.
In the PrA group, an improvement in atopic dermatitis symptoms was observed.
Ceramide expression in the skin decreased in the AD group compared to the control group, but no decrease was observed in the PrA group.
mRNA expression of ceramidase decreased in the PrA group compared to the AD group.
The results of this study have revealed that PrA inhibits itching in atopic dermatitis by preventing the skin from drying.
It is considered that the mechanism by which PrA prevents the skin from drying involves the inhibition of increased ceramidase expression associated with atopic dermatitis.
American Psychological Association (APA)
Ikarashi, Nobutomo& Sato, Wataru& Toda, Takahiro& Ishii, Makoto& Ochiai, Wataru& Sugiyama, Kiyoshi. 2011. Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1027970
Modern Language Association (MLA)
Ikarashi, Nobutomo…[et al.]. Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1027970
American Medical Association (AMA)
Ikarashi, Nobutomo& Sato, Wataru& Toda, Takahiro& Ishii, Makoto& Ochiai, Wataru& Sugiyama, Kiyoshi. Inhibitory Effect of Polyphenol-Rich Fraction from the Bark of Acacia mearnsii on Itching Associated with Allergic Dermatitis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1027970
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027970