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Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells
Joint Authors
Kim, Youn-Chul
Li, Bin
Lee, Dong-Sung
Choi, Hyun-Gyu
Kim, Kyoung-Su
Jeong, Gil-Saeng
An, Ren Bo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-24
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
A number of diseases that lead to injury of the central nervous system are caused by oxidative stress and inflammation in the brain.
In this study, NNMBS275, consisting of the ethanol extract of Viola patrinii, showed potent antioxidative and anti-inflammatory activity in murine hippocampal HT22 cells and BV2 microglia.
NNMBS275 increased cellular resistance to oxidative injury caused by glutamate-induced neurotoxicity and reactive oxygen species generation in HT22 cells.
In addition, the anti-inflammatory effects of NNMBS275 were demonstrated by the suppression of proinflammatory mediators, including proinflammatory enzymes (inducible nitric oxide synthase and cyclooxygenase-2) and cytokines (tumor necrosis factor-α and interleukin-1β).
Furthermore, we found that the neuroprotective and anti-inflammatory effects of NNMBS275 were linked to the upregulation of nuclear transcription factor-E2-related factor 2-dependent expression of heme oxygenase-1 in HT22 and BV2 cells.
These results suggest that NNMBS275 possesses therapeutic potential against neurodegenerative diseases that are induced by oxidative stress and neuroinflammation.
American Psychological Association (APA)
Li, Bin& Lee, Dong-Sung& Choi, Hyun-Gyu& Kim, Kyoung-Su& Jeong, Gil-Saeng& An, Ren Bo…[et al.]. 2012. Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1027983
Modern Language Association (MLA)
Li, Bin…[et al.]. Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1027983
American Medical Association (AMA)
Li, Bin& Lee, Dong-Sung& Choi, Hyun-Gyu& Kim, Kyoung-Su& Jeong, Gil-Saeng& An, Ren Bo…[et al.]. Involvement of Heme Oxygenase-1 Induction in the Cytoprotective and Immunomodulatory Activities of Viola patrinii in Murine Hippocampal and Microglia Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1027983
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027983