![](/images/graphics-bg.png)
Antioxidant, Antinociceptive, and Anti-Inflammatory Activities from Actinidia callosa var. callosa In Vitro and In Vivo
Joint Authors
Liao, Jung-Chun
Deng, Jeng-Shyan
Lee, Chao-Ying
Lee, Min-Min
Huang, Shyh-Shyun
Lin, Ying-Chih
Huang, Guan-Jhong
Hou, Wen-Chi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-14
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
Actinidia callosa var.
callosa has been widely used to treat antipyretic, analgesic, anti-inflammation, abdominal pain, and fever in Taiwan.
The aim of this study was to evaluate the antioxidant, antinociceptive, and anti-inflammatory lipopolysaccharide-(LPS-)induced nitric oxide (NO) production in RAW264.7 macrophages and pawedema induced by λ-carrageenan activities of the methanol extract from A.
callosa.
In HPLC analysis, the fingerprint chromatogram of ethyl-acetate fraction of A.
callosa (EAAC) was established.
EAAC showed the highest TEAC and DPPH radical scavenging activities, respectively.
We evaluated that EAAC and the reference compound of catechin and caffeic acid decreased the LPS-induced NO production in RAW264.7 cells.
Treatment of male ICR mice with EAAC significantly inhibited the numbers of acetic acid-induced writhing response and the formalin-induced pain in the late phase.
Administration of EAAC showed a concentration-dependent inhibition on paw edema development after Carr treatment in mice.
Anti-inflammatory mechanisms of EAAC might be correlated to the expression of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX-2), and heme oxygenase-1 (HO-1) in vitro and in vivo.
Overall, the results showed that EAAC demonstrated antioxidant, antinociceptive, and anti-inflammatory activity, which supports previous claims of the traditional use for inflammation and pain.
American Psychological Association (APA)
Liao, Jung-Chun& Deng, Jeng-Shyan& Lin, Ying-Chih& Lee, Chao-Ying& Lee, Min-Min& Hou, Wen-Chi…[et al.]. 2012. Antioxidant, Antinociceptive, and Anti-Inflammatory Activities from Actinidia callosa var. callosa In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1027985
Modern Language Association (MLA)
Liao, Jung-Chun…[et al.]. Antioxidant, Antinociceptive, and Anti-Inflammatory Activities from Actinidia callosa var. callosa In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1027985
American Medical Association (AMA)
Liao, Jung-Chun& Deng, Jeng-Shyan& Lin, Ying-Chih& Lee, Chao-Ying& Lee, Min-Min& Hou, Wen-Chi…[et al.]. Antioxidant, Antinociceptive, and Anti-Inflammatory Activities from Actinidia callosa var. callosa In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1027985
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027985