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Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice
Joint Authors
Peng, Wen-Huang
Liao, Jung-Chun
Chang, Ching-Wen
Chang, Wen-Te
Chiu, Yung-Jia
Hsieh, Ming-Tsuen
Lin, Yu-Chin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-06
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The aim of this study was to investigate possible analgesic and anti-inflammatory mechanisms of the CRMeOH.
Analgesic effect was evaluated in two models including acetic acid-induced writhing response and formalin-induced paw licking.
The anti-inflammatory effect was evaluated by λ-carrageenan-induced mouse paw edema and histopathologic analyses.
The results showed that CRMeOH (500 mg/kg) decreased writhing response in the acetic acid assay and licking time in the formalin test.
CRMeOH (100 and 500 mg/kg) significantly decreased edema paw volume at 4th to 5th hours after λ-carrageenan had been injected.
Histopathologically, CRMeOH abated the level of tissue destruction and swelling of the edema paws.
These results were indicated that anti-inflammatory mechanism of CRMeOH may be due to declined levels of NO and MDA in the edema paw through increasing the activities of SOD, GPx, and GRd in the liver.
Additionally, CRMeOH also decreased IL-1β, IL-6, NFκB, TNF-α, COX-2, and iNOS levels.
The contents of two active ingredients, ursolic acid and lupeol, were quantitatively determined.
This paper demonstrated possible mechanisms for the analgesic and anti-inflammatory effects of CRMeOH and provided evidence for the classical treatment of Cissus repens in inflammatory diseases.
American Psychological Association (APA)
Chang, Ching-Wen& Chang, Wen-Te& Liao, Jung-Chun& Chiu, Yung-Jia& Hsieh, Ming-Tsuen& Peng, Wen-Huang…[et al.]. 2012. Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1027997
Modern Language Association (MLA)
Chang, Ching-Wen…[et al.]. Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1027997
American Medical Association (AMA)
Chang, Ching-Wen& Chang, Wen-Te& Liao, Jung-Chun& Chiu, Yung-Jia& Hsieh, Ming-Tsuen& Peng, Wen-Huang…[et al.]. Analgesic and Anti-Inflammatory Activities of Methanol Extract of Cissus repens in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1027997
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027997