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Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition
Joint Authors
Mohamed Elhassan Taha, Manal
Alkharfy, Khalid M.
Mohamed, Abdelwahab Hassan
Mohamed, Osama Yousif
Oall, Mahjoub
Noordin, Mohamed Ibrahim
Mustafa, Mohd Rais
Abdel Wahab, Siddig Ibrahim
Mohan, Syam
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-13
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Clerodendron capitatum (Willd) (family: verbenaceae) is locally named as Gung and used traditionally to treat erectile dysfunction.
Therefore, the current study was designed to investigate the erectogenic properties of C.
capitatum.
The relaxation effect of this plant was tested on phenylephrine precontracted rabbit corpus cavernosum smooth muscle (CCSM).
The effects of C.
capitatum were also examined on isolated Guinea pig atria alone, in the presence of calcium chloride (Ca2+ channel blocker), atropine (cholinergic blocker), and glibenclamide (ATP-sensitive K+ channel blocker).
These effects were confirmed on isolated rabbit aortic strips.
The extract, when tested colorimetrically for its inhibitory activities on phosphordiesterase-5 (PDE-5) in vitro towards p-nitrophenyl phenyl phosphate (PNPPP), was observed to induce significant dose-dependent inhibition of PDE-5, with an ID50 of 0.161 mg/ml (P<.05).
In conclusion, our results suggest that C.
capitatum possesses a relaxant effect on CCSM, which is attributable to the inhibition of PDE-5, but not mediated by the release calcium, activation of adrenergic or cholinergic receptors, or the activation of potassium channels.
American Psychological Association (APA)
Abdel Wahab, Siddig Ibrahim& Mohamed, Abdelwahab Hassan& Mohamed, Osama Yousif& Oall, Mahjoub& Mohamed Elhassan Taha, Manal& Mohan, Syam…[et al.]. 2011. Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1027999
Modern Language Association (MLA)
Abdel Wahab, Siddig Ibrahim…[et al.]. Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1027999
American Medical Association (AMA)
Abdel Wahab, Siddig Ibrahim& Mohamed, Abdelwahab Hassan& Mohamed, Osama Yousif& Oall, Mahjoub& Mohamed Elhassan Taha, Manal& Mohan, Syam…[et al.]. Erectogenic Effects of Clerodendron capitatum: Involvement of Phosphodiesterase Type-5 Inhibition. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1027999
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1027999