Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery
Joint Authors
Lu, Cheng
Li, Jian
Lu, Aiping
Niu, Xuyan
Jiang, Miao
Guo, Hongtao
Bian, Zhaoxiang
Li, Li
Lin, Na
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-11
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Current strategies for drug discovery have reached a bottleneck where the paradigm is generally “one gene, one drug, one disease.” However, using holistic and systemic views, network pharmacology may be the next paradigm in drug discovery.
Based on network pharmacology, a combinational drug with two or more compounds could offer beneficial synergistic effects for complex diseases.
Interestingly, traditional chinese medicine (TCM) has been practicing holistic views for over 3,000 years, and its distinguished feature is using herbal formulas to treat diseases based on the unique pattern classification.
Though TCM herbal formulas are acknowledged as a great source for drug discovery, no drug discovery strategies compatible with the multidimensional complexities of TCM herbal formulas have been developed.
In this paper, we highlighted some novel paradigms in TCM-based network pharmacology and new drug discovery.
A multiple compound drug can be discovered by merging herbal formula-based pharmacological networks with TCM pattern-based disease molecular networks.
Herbal formulas would be a source for multiple compound drug candidates, and the TCM pattern in the disease would be an indication for a new drug.
American Psychological Association (APA)
Li, Jian& Lu, Cheng& Jiang, Miao& Niu, Xuyan& Guo, Hongtao& Li, Li…[et al.]. 2012. Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028014
Modern Language Association (MLA)
Li, Jian…[et al.]. Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028014
American Medical Association (AMA)
Li, Jian& Lu, Cheng& Jiang, Miao& Niu, Xuyan& Guo, Hongtao& Li, Li…[et al.]. Traditional Chinese Medicine-Based Network Pharmacology Could Lead to New Multicompound Drug Discovery. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028014
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028014