Bioassay-Guided Isolation of Cytotoxic Cycloartane Triterpenoid Glycosides from the Traditionally Used Medicinal Plant Leea indica
Joint Authors
Yau Hsiung, Wong
Abdul Kadir, Habsah
Ling, Sui Kiong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-11-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Leea indica is a medicinal plant used traditionally to cure cancer.
In this study, the cytotoxic compounds of L.
indica were isolated using bioassay-guided approach.
Two cycloartane triterpenoid glycosides, mollic acid arabinoside (MAA) and mollic acid xyloside (MAX), were firstly isolated from L.
indica.
They inhibited the growth of Ca Ski cervical cancer cells with IC50 of 19.21 μM (MAA) and 33.33 μM (MAX).
MRC5 normal cell line was used to calculate selectivity index.
MAA and MAX were about 8 and 4 times more cytotoxic to Ca Ski cells compared to MRC5.
The cytotoxicity of MAA was characterized by both cytostatic and cytocidal effects.
MAA decreased the expression of proliferative cell nuclear antigen, increased sub-G1 cells, and arrested cells in S and G2/M phases.
This study provides the evidence for the ethnomedicinal use of L.
indica and paves the way for future mechanism studies on the anticancer effects of MAA.
American Psychological Association (APA)
Yau Hsiung, Wong& Abdul Kadir, Habsah& Ling, Sui Kiong. 2011. Bioassay-Guided Isolation of Cytotoxic Cycloartane Triterpenoid Glycosides from the Traditionally Used Medicinal Plant Leea indica. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028136
Modern Language Association (MLA)
Yau Hsiung, Wong…[et al.]. Bioassay-Guided Isolation of Cytotoxic Cycloartane Triterpenoid Glycosides from the Traditionally Used Medicinal Plant Leea indica. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028136
American Medical Association (AMA)
Yau Hsiung, Wong& Abdul Kadir, Habsah& Ling, Sui Kiong. Bioassay-Guided Isolation of Cytotoxic Cycloartane Triterpenoid Glycosides from the Traditionally Used Medicinal Plant Leea indica. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028136
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028136