![](/images/graphics-bg.png)
Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats
Joint Authors
Chua, Kek Heng
Tan, Yee-Shin
Wong, Wei-Lun
Sabaratnam, Vikineswary
Kuppusamy, Umah Rani
Abdulla, Mahmood Ameen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-09
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Panus giganteus, a culinary and medicinal mushroom consumed by selected indigenous communities in Malaysia, is currently being considered for large scale cultivation.
This study was undertaken to investigate the hepatoprotective effects of P.
giganteus against thioacetamide- (TAA-) induced liver injury in Sprague-Dawley rats.
The rats were injected intraperitoneally with TAA thrice weekly and were orally administered freeze-dried fruiting bodies of P.
giganteus (0.5 or 1 g/kg) daily for two months, while control rats were given vehicle or P.
giganteus only.
After 60 days, rats administered with P.
giganteus showed lower liver body weight ratio, restored levels of serum liver biomarkers and oxidative stress parameters comparable to treatment with the standard drug silymarin.
Gross necropsy and histopathological examination further confirmed the hepatoprotective effects of P.
giganteus.
This is the first report on hepatoprotective effects of P.
giganteus.
The present study showed that P.
giganteus was able to prevent or reduce the severity of TAA-induced liver injury.
American Psychological Association (APA)
Wong, Wei-Lun& Abdulla, Mahmood Ameen& Chua, Kek Heng& Kuppusamy, Umah Rani& Tan, Yee-Shin& Sabaratnam, Vikineswary. 2012. Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028145
Modern Language Association (MLA)
Wong, Wei-Lun…[et al.]. Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028145
American Medical Association (AMA)
Wong, Wei-Lun& Abdulla, Mahmood Ameen& Chua, Kek Heng& Kuppusamy, Umah Rani& Tan, Yee-Shin& Sabaratnam, Vikineswary. Hepatoprotective Effects of Panus giganteus (Berk.) Corner against Thioacetamide- (TAA-) Induced Liver Injury in Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028145
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028145