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Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula
Joint Authors
Huang, Zhen
Zhong, Xiao-Ming
Li, Zhao-Yi
Mao, Qing-Qiu
Ip, Paul Siu-Po
Fengmei, Qiu
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-7, 7 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-09
Country of Publication
Egypt
No. of Pages
7
Main Subjects
Abstract EN
Danggui-Shaoyao-San (DSS), a famous Chinese herbal formula, has been widely used in the treatment of various diseases.
Previous studies have shown that DSS produces antidepressant-like effect in rodents.
This study aims to investigate the mechanism(s) underlying the antidepressant-like action of DDS.
The results showed that DSS treatment significantly antagonized reserpine-induced ptosis in mice.
In addition, DSS treatment significantly increased sucrose consumption in chronic unpredictable stress- (CUS-) treated mice.
DSS treatment also markedly attenuated CUS-induced decreases in noradrenaline and dopamine concentrations in mouse brain.
Furthermore, DSS treatment significantly reversed CUS-induced increase in serum malondialdehyde (MDA) content and decrease in serum superoxide dismutase (SOD) activity in mice.
The results suggest that the antidepressant-like activity of DSS is probably mediated by the modulation of central monoamine neurotransmitter systems and the reduction of oxidative stress.
American Psychological Association (APA)
Huang, Zhen& Mao, Qing-Qiu& Zhong, Xiao-Ming& Li, Zhao-Yi& Fengmei, Qiu& Ip, Paul Siu-Po. 2012. Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028156
Modern Language Association (MLA)
Huang, Zhen…[et al.]. Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-7.
https://search.emarefa.net/detail/BIM-1028156
American Medical Association (AMA)
Huang, Zhen& Mao, Qing-Qiu& Zhong, Xiao-Ming& Li, Zhao-Yi& Fengmei, Qiu& Ip, Paul Siu-Po. Mechanistic Study on the Antidepressant-Like Effect of Danggui-Shaoyao-San, a Chinese Herbal Formula. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-7.
https://search.emarefa.net/detail/BIM-1028156
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028156