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Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo
Joint Authors
Lee, Soo Jin
Cho, Sun-A
An, Su-Sun
Na, Yong-Joo
Park, Nok-Hyun
Kim, Han-Sung
Lee, Chan-Woo
Kim, Han-Kon
Kim, Eun-Kyung
Kim, Jin-Woong
Jang, Young Pyo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-08
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Topical retinoids inhibit matrix metalloproteinases and accelerate collagen synthesis, thereby triggering antiaging effects in the skin.
However, topical retinoids can cause severe skin reactions, including scaling, erythema, papules, and inflammation.
The present study demonstrates that the ethanolic bark extract of Alstonia scholaris R.
Br.
can significantly inhibit all-trans retinoic acid-induced inflammation in human HaCat keratinocyte cells.
Furthermore, two representative retinoid-induced proinflammatory cytokines, monocyte chemoattractant protein-1 and interleukin-8, were significantly suppressed by A.
scholaris extract (by 82.1% and 26.3% at 100 ppm, and dose-dependently across the tested concentrations) in vitro.
In a cumulative irritation patch test, A.
scholaris extract decreased retinol-induced skin irritation, while strengthening the ability of retinoids to inhibit matrix metalloproteinase-1 expression, which is strongly associated with aging effects.
These results suggest that A.
scholaris is a promising compound that may increase the antiaging function of retinoids while reducing their ability to cause skin irritation.
American Psychological Association (APA)
Lee, Soo Jin& Cho, Sun-A& An, Su-Sun& Na, Yong-Joo& Park, Nok-Hyun& Kim, Han-Sung…[et al.]. 2011. Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028162
Modern Language Association (MLA)
Lee, Soo Jin…[et al.]. Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028162
American Medical Association (AMA)
Lee, Soo Jin& Cho, Sun-A& An, Su-Sun& Na, Yong-Joo& Park, Nok-Hyun& Kim, Han-Sung…[et al.]. Alstonia scholaris R. Br. Significantly Inhibits Retinoid-Induced Skin Irritation In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028162
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028162