Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine
Joint Authors
Lu, Cheng
Lu, Aiping
Niu, Xuyan
Jiang, Miao
Xiao, Cheng
Chen, Gao
Guo, Hongtao
Zha, Qinglin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-17, 17 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-22
Country of Publication
Egypt
No. of Pages
17
Main Subjects
Abstract EN
In Traditional Chinese Medicine (TCM), patients with Rheumatoid Arthritis (RA) can be classified into two main patterns: cold-pattern and heat-pattern.
This paper identified the network-based gene expression biomarkers for both cold- and heat-patterns of RA.
Gene expression profilings of CD4+ T cells from cold-pattern RA patients, heat-pattern RA patients, and healthy volunteers were obtained using microarray.
The differentially expressed genes and related networks were explored using DAVID, GeneSpring software, and the protein-protein interactions (PPI) method.
EIF4A2, CCNT1, and IL7R, which were related to the up-regulation of cell proliferation and the Jak-STAT cascade, were significant gene biomarkers of the TCM cold pattern of RA.
PRKAA1, HSPA8, and LSM6, which were related to fatty acid metabolism and the I-κB kinase/NF-κB cascade, were significant biomarkers of the TCM heat-pattern of RA.
The network-based gene expression biomarkers for the TCM cold- and heat-patterns may be helpful for the further stratification of RA patients when deciding on interventions or clinical trials.
American Psychological Association (APA)
Lu, Cheng& Niu, Xuyan& Xiao, Cheng& Chen, Gao& Zha, Qinglin& Guo, Hongtao…[et al.]. 2012. Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-1028169
Modern Language Association (MLA)
Lu, Cheng…[et al.]. Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-17.
https://search.emarefa.net/detail/BIM-1028169
American Medical Association (AMA)
Lu, Cheng& Niu, Xuyan& Xiao, Cheng& Chen, Gao& Zha, Qinglin& Guo, Hongtao…[et al.]. Network-Based Gene Expression Biomarkers for Cold and Heat Patterns of Rheumatoid Arthritis in Traditional Chinese Medicine. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-17.
https://search.emarefa.net/detail/BIM-1028169
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028169