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An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study
Joint Authors
Agarwal, Amit
Raveendra, Kadur Ramamurthy
Jayachandra, Kadur Ramamurthy
Srinivasa, Venkatappa
Sushma, Kadur Raveendra
Geetharani, Periasamy
Goudar, Krishnagouda Shankargouda
Shivaprasad, Hebbani Nagarajappa
Venkateshwarlu, Kudiganti
Sushma, Gopalakrishna
Allan, Joseph Joshua
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-05-05
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
A randomized, double-blind, placebo-controlled study was conducted to evaluate the efficacy of GutGard, an extract of Glycyrrhiza glabra, in patients with functional dyspepsia.
The primary outcome variables of the study were the change in the severity symptoms and the global assessment of efficacy.
The quality of life was evaluated as a secondary outcome measure.
The patients received either placebo or GutGard (75 mg twice daily) for 30 days.
Efficacy was evaluated in terms of change in the severity of symptoms (as measured by 7-point Likert scale), the global assessment of efficacy, and the assessment of quality of life using the short-form Nepean Dyspepsia Index.
In comparison with placebo, GutGard showed a significant decrease ( P ≤ .05 ) in total symptom scores on day 15 and day 30, respectively.
Similarly, GutGard showed marked improvement in the global assessment of efficacy in comparison to the placebo.
The GutGard group also showed a significant decrease ( P ≤ .05 ) in the Nepean dyspepsia index on day 15 and 30, respectively, when compared to placebo.
GutGard was generally found to be safe and well-tolerated by all patients.
GutGard has shown significant efficacy in the management of functional dyspepsia.
American Psychological Association (APA)
Raveendra, Kadur Ramamurthy& Jayachandra, Kadur Ramamurthy& Srinivasa, Venkatappa& Sushma, Kadur Raveendra& Allan, Joseph Joshua& Goudar, Krishnagouda Shankargouda…[et al.]. 2011. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028175
Modern Language Association (MLA)
Raveendra, Kadur Ramamurthy…[et al.]. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028175
American Medical Association (AMA)
Raveendra, Kadur Ramamurthy& Jayachandra, Kadur Ramamurthy& Srinivasa, Venkatappa& Sushma, Kadur Raveendra& Allan, Joseph Joshua& Goudar, Krishnagouda Shankargouda…[et al.]. An Extract of Glycyrrhiza glabra (GutGard) Alleviates Symptoms of Functional Dyspepsia: A Randomized, Double-Blind, Placebo-Controlled Study. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028175
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028175