Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice
Joint Authors
Cao, Hui-Juan
Tan, Rui-Rong
Tang, Lu-Ping
Wang, Xin-Luan
Yao, Nan
Duan, Wen-Jun
Hu, Yuan-Ao
Yao, Xin-Sheng
Kurihara, Hiroshi
He, Rong-Rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-11-01
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Sarcandra glabra, as a type of “antipyretic-detoxicate drugs”, has always been widely used in traditional Chinese medicine (TCM).
The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine.
However, relative experiment data supporting this effective clinical consequence was limited.
In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza.
Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days.
Body weight, morbidity, and mortality were recorded daily.
Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined.
Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus.
However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time.
The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-κB protein expression to ameliorate the lung injury.
These data showed that SGE reduced the susceptibility and severity of influenza.
American Psychological Association (APA)
Cao, Hui-Juan& Tan, Rui-Rong& He, Rong-Rong& Tang, Lu-Ping& Wang, Xin-Luan& Yao, Nan…[et al.]. 2012. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028180
Modern Language Association (MLA)
Tan, Rui-Rong…[et al.]. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028180
American Medical Association (AMA)
Cao, Hui-Juan& Tan, Rui-Rong& He, Rong-Rong& Tang, Lu-Ping& Wang, Xin-Luan& Yao, Nan…[et al.]. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028180
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028180