Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice

Joint Authors

Cao, Hui-Juan
Tan, Rui-Rong
Tang, Lu-Ping
Wang, Xin-Luan
Yao, Nan
Duan, Wen-Jun
Hu, Yuan-Ao
Yao, Xin-Sheng
Kurihara, Hiroshi
He, Rong-Rong

Source

Evidence-Based Complementary and Alternative Medicine

Issue

Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.

Publisher

Hindawi Publishing Corporation

Publication Date

2012-11-01

Country of Publication

Egypt

No. of Pages

12

Main Subjects

Medicine

Abstract EN

Sarcandra glabra, as a type of “antipyretic-detoxicate drugs”, has always been widely used in traditional Chinese medicine (TCM).

The Sarcandra glabra extract (SGE) is applied frequently as anti-inflammatory and anti-infectious drug in folk medicine.

However, relative experiment data supporting this effective clinical consequence was limited.

In order to mimic the physiological conditions of the susceptible population, we employed restraint stress mouse model to investigate the effect of SGE against influenza.

Mice were infected with influenza virus three days after restraint, while SGE was orally administrated for 10 consecutive days.

Body weight, morbidity, and mortality were recorded daily.

Histopathologic changes, susceptibility genes expressions and inflammatory markers in lungs were determined.

Our results showed that restraint stress significantly increased susceptibility and severity of influenza virus.

However, oral administration of SGE could reduce morbidity, mortality and significantly prolonged survival time.

The results further showed that SGE had a crucial effect on improving susceptibility markers levels to recover the balance of host defense system and inhibiting inflammatory cytokines levels through down-regulation of NF-κB protein expression to ameliorate the lung injury.

These data showed that SGE reduced the susceptibility and severity of influenza.

American Psychological Association (APA)

Cao, Hui-Juan& Tan, Rui-Rong& He, Rong-Rong& Tang, Lu-Ping& Wang, Xin-Luan& Yao, Nan…[et al.]. 2012. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028180

Modern Language Association (MLA)

Tan, Rui-Rong…[et al.]. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028180

American Medical Association (AMA)

Cao, Hui-Juan& Tan, Rui-Rong& He, Rong-Rong& Tang, Lu-Ping& Wang, Xin-Luan& Yao, Nan…[et al.]. Sarcandra glabra Extract Reduces the Susceptibility and Severity of Influenza in Restraint-Stressed Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028180

Data Type

Journal Articles

Language

English

Notes

Includes bibliographical references

Record ID

BIM-1028180