Inhibition of NO2, PGE2, TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity
Joint Authors
Haldar, Pallab K.
Debprasad, Chattopadhyay
Hemanta, Mukherjee
Paromita, Bag
Durbadal, Ojha
Kumar, Konreddy Ananda
Shanta, Dutta
Tapan, Chatterjee
Ashoke, Sharon
Sekhar, Chakraborti
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-10
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This paper is an attempt to evaluate the anti-inflammatory and analgesic activities and the possible mechanism of action of tender leaf extracts of Shorea robusta, traditionally used in ailments related to inflammation.
The acetic-acid-induced writhing and tail flick tests were carried out for analgesic activity, while the anti-inflammatory activity was evaluated in carrageenan-and dextran- induced paw edema and cotton-pellet-induced granuloma model.
The acetic-acid-induced vascular permeability, erythrocyte membrane stabilization, release of proinflammatory mediators (nitric oxide and prostaglandin E2), and cytokines (tumor necrosis factor-α, and interleukins-1β and -6) from lipopolysaccharide-stimulated human monocytic cell lines were assessed to understand the mechanism of action.
The results revealed that both aqueous and methanol extract (400 mg/kg) caused significant reduction of writhing and tail flick, paw edema, granuloma tissue formation (P<0.01), vascular permeability, and membrane stabilization.
Interestingly, the aqueous extract at 40 μg/mL significantly inhibited the production of NO and release of PGE2, TNF-α, IL-1β, and IL-6.
Chemically the extract contains flavonoids and triterpenes and toxicity study showed that the extract is safe.
Thus, our study validated the scientific rationale of ethnomedicinal use of S.
robusta and unveils its mechanism of action.
However, chronic toxicological studies with active constituents are needed before its use.
American Psychological Association (APA)
Debprasad, Chattopadhyay& Hemanta, Mukherjee& Paromita, Bag& Durbadal, Ojha& Kumar, Konreddy Ananda& Shanta, Dutta…[et al.]. 2012. Inhibition of NO2, PGE2, TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028190
Modern Language Association (MLA)
Debprasad, Chattopadhyay…[et al.]. Inhibition of NO2, PGE2, TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-14.
https://search.emarefa.net/detail/BIM-1028190
American Medical Association (AMA)
Debprasad, Chattopadhyay& Hemanta, Mukherjee& Paromita, Bag& Durbadal, Ojha& Kumar, Konreddy Ananda& Shanta, Dutta…[et al.]. Inhibition of NO2, PGE2, TNF-α, and iNOS EXpression by Shorea robusta L.: An Ethnomedicine Used for Anti-Inflammatory and Analgesic Activity. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-14.
https://search.emarefa.net/detail/BIM-1028190
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028190