The Crude Extract from Puerariae Flower Exerts Antiobesity and Antifatty Liver Effects in High-Fat Diet-Induced Obese Mice
Joint Authors
Shimada, Tsutomu
Takagaki, Kinya
Sameshima-Kamiya, Mayu
Nagamine, Rika
Kamiya, Tomoyasu
Tsubata, Masahito
Ikeguchi, Motoya
Aburada, Masaki
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-27
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Kudzu, a leguminous plant, has long been used in folk medicine.
In particular, its flowers are used in Japanese and Chinese folk medicine for treating hangovers.
We focused on the flower of Kudzu (Puerariae thomsonii), and we previously reported the antiobesity effect of Puerariae thomsonii flower extract (PFE) in humans.
In this study, we conducted an animal study to investigate the effect of PFE on visceral fat and hepatic lipid levels in mice with diet-induced obesity.
In addition, we focused on gene expression profiles to investigate the antiobesity mechanism of PFE.
Male C57BL/6J mice were fed a high-fat diet (HFD) or an HFD supplemented with 5% PFE for 14 days.
PFE supplementation significantly reduced body weight and white adipose tissue (WAT) weight.
Moreover, in the histological analysis, PFE supplementation improved fatty liver.
Hepatic reverse transcription-polymerase chain reaction revealed that PFE supplementation downregulated acetyl-CoA carboxylase expression.
For adipose tissue, the expressions of hormone-sensitive lipase in WAT and uncoupling protein 1 in brown adipose tissue (BAT) were significantly upregulated.
These results suggest that PFE exerts antiobesity and antifatty liver effects in high-fat diet-induced obese mice through suppressing lipogenesis in the liver, stimulating lipolysis in WAT, and promoting thermogenesis in BAT.
American Psychological Association (APA)
Kamiya, Tomoyasu& Sameshima-Kamiya, Mayu& Nagamine, Rika& Tsubata, Masahito& Ikeguchi, Motoya& Takagaki, Kinya…[et al.]. 2012. The Crude Extract from Puerariae Flower Exerts Antiobesity and Antifatty Liver Effects in High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028212
Modern Language Association (MLA)
Kamiya, Tomoyasu…[et al.]. The Crude Extract from Puerariae Flower Exerts Antiobesity and Antifatty Liver Effects in High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028212
American Medical Association (AMA)
Kamiya, Tomoyasu& Sameshima-Kamiya, Mayu& Nagamine, Rika& Tsubata, Masahito& Ikeguchi, Motoya& Takagaki, Kinya…[et al.]. The Crude Extract from Puerariae Flower Exerts Antiobesity and Antifatty Liver Effects in High-Fat Diet-Induced Obese Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028212
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028212