The Chinese Herbal Decoction Danggui Buxue Tang Inhibits Angiogenesis in a Rat Model of Liver Fibrosis
Joint Authors
Wang, Qinglan
Lv, Jing
Zhao, Zhimin
Chen, Yuan
Yang, Li
Fan, Tai-Ping
Tao, Yanyan
Liu, Chenghai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-07-29
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
In this study, we investigated the anti-angiogenic effect of the Chinese herbal decoction Danggui BuxueTang (DBT; Radix Astragali and Radix Angelicae sinensis in 5 : 1 ratio) in a rat model of liver fibrosis, inorder to elucidate its mechanisms of action against liver fibrosis.
Liver fibrosis was induced with CCl4 andhigh-fat food for 6 weeks, and the rats were treated with oral doses of DBT (6 g raw herbs/kg/d) and N-Acetyl-L-cysteine (NAC; 0.1 g/kg/d).
The results showed that both DBT and NAC attenuated liver fibrosis and neo-angiogenesis.
Furthermore, DBT and NAC improved SOD activity but decreased MDA content and 8-OH-dG in fibrotic livers, with DBT being more effective than NAC.
DBT decreased theexpression of VEGF, Ang1 and TGF-β1 and their signaling mediators, whereas NAC had no effect on VEGFand VEGFR2 expression.
Both DBT and NAC reduced HIF-1α gene and protein expression in fibrotic livers,with DBT being more effective.
These data clearly demonstrate that the anti-fibrotic properties of DBT arerelated to its ability to inhibit angiogenesis and its anti-angiogenic mechanisms are associated withimproving oxidative stress, regulating the expression and signaling of angiogenic factors, and especiallymodulating HIF-1α in fibrotic livers.
American Psychological Association (APA)
Lv, Jing& Zhao, Zhimin& Chen, Yuan& Wang, Qinglan& Tao, Yanyan& Yang, Li…[et al.]. 2012. The Chinese Herbal Decoction Danggui Buxue Tang Inhibits Angiogenesis in a Rat Model of Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028232
Modern Language Association (MLA)
Lv, Jing…[et al.]. The Chinese Herbal Decoction Danggui Buxue Tang Inhibits Angiogenesis in a Rat Model of Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028232
American Medical Association (AMA)
Lv, Jing& Zhao, Zhimin& Chen, Yuan& Wang, Qinglan& Tao, Yanyan& Yang, Li…[et al.]. The Chinese Herbal Decoction Danggui Buxue Tang Inhibits Angiogenesis in a Rat Model of Liver Fibrosis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028232
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028232