Interleukin-10 Genotype Correlated to Deficiency Syndrome in Hepatitis B Cirrhosis
Joint Authors
Liang, Jian
Gao, Yue-Qiu
Xue, Dong-Ying
Xu, Lie-Ming
Zhang, Wei
Li, Qing-ya
Guo, Zhi-Zhong
Su, Shi-Bing
Wang, Xiao-Su
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-28
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Traditional Chinese medicine (TCM) syndrome is an important basis for TCM diagnosis and treatment.
As Child-Pugh classification as well as compensation and decompensation phase in liver cirrhosis, it is also an underlying clinical classification.
In this paper, we investigated the correlation between single nucleotide polymorphisms (SNPs) of Interleukin-10 (IL-10) and TCM syndromes in patients with hepatitis B cirrhosis (HBC).
Samples were obtained from 343 HBC patients in China.
Three SNPs of IL-10 (−592A/C, −819C/T, and −1082A/G) were detected with polymerase chain-reaction-ligase detection reaction (PCR-LDR).
The result showed the SNP-819C/T was significantly correlated with Deficiency syndrome (P=0.031), but none of the 3 loci showed correlation either with Child-Pugh classification and phase in HBC patients.
The logistic regression analysis showed that the Excess syndrome was associated with dizzy and spider nevus, and the Deficiency syndrome was associated with dry eyes, aversion to cold, IL-10-819C/T loci, and IL-10-1082A/G loci.
The odds ratio (OR) value at IL-10-819C/T was 4.022.
The research results suggested that IL-10-819C/T locus (TC plus CC genotype) is probably a risk factor in the occurrence of Deficiency syndrome in HBC patients.
American Psychological Association (APA)
Li, Qing-ya& Guo, Zhi-Zhong& Liang, Jian& Zhang, Wei& Xu, Lie-Ming& Gao, Yue-Qiu…[et al.]. 2012. Interleukin-10 Genotype Correlated to Deficiency Syndrome in Hepatitis B Cirrhosis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028242
Modern Language Association (MLA)
Li, Qing-ya…[et al.]. Interleukin-10 Genotype Correlated to Deficiency Syndrome in Hepatitis B Cirrhosis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028242
American Medical Association (AMA)
Li, Qing-ya& Guo, Zhi-Zhong& Liang, Jian& Zhang, Wei& Xu, Lie-Ming& Gao, Yue-Qiu…[et al.]. Interleukin-10 Genotype Correlated to Deficiency Syndrome in Hepatitis B Cirrhosis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028242
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028242