Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function
Joint Authors
Zou, Zhongmei
Tao, Xu
Jing-bo, Peng
Wen-tong, Zhang
Xin, Zhao
Tao-tao, Zhang
Shi-jun, Yang
Lei, Fang
Da-yong, Cai
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-09-12
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Including herbal medicine, complementary and alternative medicine (CAM) is popular worldwide.
The traditional Chinese medicine xinkeshu has been widely used to treat coronary heart disease in China.
This study was designed to investigate the protective effect and probable mechanism of xinkeshu tablet to atherosclerotic myocardial ischemia rabbit.
Rabbits were divided into four groups (n=12 each) and fed with different diet for 12 weeks: Control (standard diet), Model (high-cholesterol diet), XKS (high-cholesterol diet with 184.8 mg/kg/d xinkeshu), and Atorvastatin (high-cholesterol diet with 5.0 mg/kg/d atorvastatin).
Plasma lipoprotein, ECG, endothelium-dependent vessel relaxation, histomorphological study, and expressions of eNOS and VCAM-1 on coronary arteries were assessed.
The findings showed that, similar to atorvastatin, xinkeshu presented significant effects on rescuing endothelium-dependent vessel relaxation, inhibiting atherosclerotic progress, preventing myocardial ischemia, and changing eNOS and VCAM-1 expression.
However, xinkeshu showed no lipoprotein lowering effect in hypercholesterolemia rabbits.
The results of the present study indicated that xinkeshu exerted potent antiatherogenic and anti-ischemic properties on atherosclerotic myocardial ischemia rabbit.
An endothelial protecting effect may be involved in the mechanism other than antihyperlipidemic effect.
American Psychological Association (APA)
Tao, Xu& Jing-bo, Peng& Wen-tong, Zhang& Xin, Zhao& Tao-tao, Zhang& Shi-jun, Yang…[et al.]. 2011. Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028243
Modern Language Association (MLA)
Tao, Xu…[et al.]. Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028243
American Medical Association (AMA)
Tao, Xu& Jing-bo, Peng& Wen-tong, Zhang& Xin, Zhao& Tao-tao, Zhang& Shi-jun, Yang…[et al.]. Antiatherogenic and Anti-Ischemic Properties of Traditional Chinese Medicine Xinkeshu via Endothelial Protecting Function. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028243
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028243