Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum
Joint Authors
Ismail, Muhammad
Khan, Arif-ullah
Khan, Abdul Latif
Ali, Liaqat
Khan, Farman-ullah
Khan, Amir Zada
Niaz, Uzma
Lee, In-Jung
Hussain, Javid
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-09-20
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
The present study describes the phytochemical investigations of the crude extracts of rhizomes and leaves of Geranium wallichianum.
The crude extracts were fractionated to obtain n-hexane, ethyl acetate, and n-butanol fractions, which were subjected to different biological activities and enzyme inhibition assays to explore the therapeutic potential of this medicinally important herb.
The results indicated that the crude extracts and different fractions of rhizomes and leaves showed varied degree of antimicrobial activities and enzyme inhibitions in different assays.
Overall, the rhizome extract and its different fractions showed comparatively better activities in various assays.
Furthermore, the purified constituents from the repeated chromatographic separations were also subjected to enzyme inhibition studies against three different enzymes.
The results of these studies showed that lipoxygenase enzyme was significantly inhibited as compared to urease.
In case of chemical constituents, the sterols (2–4) showed no inhibition, while ursolic acid (1) and benzoic ester (6) showed significant inhibition of urease enzymes.
American Psychological Association (APA)
Ismail, Muhammad& Hussain, Javid& Khan, Arif-ullah& Khan, Abdul Latif& Ali, Liaqat& Khan, Farman-ullah…[et al.]. 2012. Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028248
Modern Language Association (MLA)
Ismail, Muhammad…[et al.]. Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028248
American Medical Association (AMA)
Ismail, Muhammad& Hussain, Javid& Khan, Arif-ullah& Khan, Abdul Latif& Ali, Liaqat& Khan, Farman-ullah…[et al.]. Antibacterial, Antifungal, Cytotoxic, Phytotoxic, Insecticidal, and Enzyme Inhibitory Activities of Geranium wallichianum. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028248
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028248