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In Vitro Cytotoxic Potential of Essential Oils of Eucalyptus benthamii and Its Related Terpenes on Tumor Cell Lines
Joint Authors
Döll-Boscardin, Patrícia Mathias
Sales Maia, Beatriz Helena Lameiro de Noronha
Padilha de Paula, Josiane
Nakashima, Tomoe
Kanunfre, Carla Cristine
Farago, Paulo Vitor
Sartoratto, A.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Eucalyptus L.
is traditionally used for many medicinal purposes.
In particular, some Eucalyptus species have currently shown cytotoxic properties.
Local Brazilian communities have used leaves of E.
benthamii as a herbal remedy for various diseases, including cancer.
Considering the lack of available data for supporting this cytotoxic effect, the goal of this paper was to study the in vitro cytotoxic potential of the essential oils from young and adult leaves of E.
benthamii and some related terpenes (α-pinene, terpinen-4-ol, and γ-terpinene) on Jurkat, J774A.1 and HeLa cells lines.
Regarding the cytotoxic activity based on MTT assay, the essential oils showed improved results than α-pinene and γ-terpinene, particularly for Jurkat and HeLa cell lines.
Terpinen-4-ol revealed a cytotoxic effect against Jurkat cells similar to that observed for volatile oils.
The results of LDH activity indicated that cytotoxic activity of samples against Jurkat cells probably involved cell death by apoptosis.
The decrease of cell DNA content was demonstrated due to inhibition of Jurkat cells proliferation by samples as a result of cytotoxicity.
In general, the essential oils from young and adult leaves of E.
benthamii presented cytotoxicity against the investigated tumor cell lines which confirms their antitumor potential.
American Psychological Association (APA)
Döll-Boscardin, Patrícia Mathias& Sartoratto, A.& Sales Maia, Beatriz Helena Lameiro de Noronha& Padilha de Paula, Josiane& Nakashima, Tomoe& Farago, Paulo Vitor…[et al.]. 2012. In Vitro Cytotoxic Potential of Essential Oils of Eucalyptus benthamii and Its Related Terpenes on Tumor Cell Lines. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028260
Modern Language Association (MLA)
Döll-Boscardin, Patrícia Mathias…[et al.]. In Vitro Cytotoxic Potential of Essential Oils of Eucalyptus benthamii and Its Related Terpenes on Tumor Cell Lines. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028260
American Medical Association (AMA)
Döll-Boscardin, Patrícia Mathias& Sartoratto, A.& Sales Maia, Beatriz Helena Lameiro de Noronha& Padilha de Paula, Josiane& Nakashima, Tomoe& Farago, Paulo Vitor…[et al.]. In Vitro Cytotoxic Potential of Essential Oils of Eucalyptus benthamii and Its Related Terpenes on Tumor Cell Lines. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028260
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028260