55-Week Treatment of Mice with the Unani and Ayurvedic Medicine Pomegranate Flower Ameliorates Ageing-Associated Insulin Resistance and Skin Abnormalities
Joint Authors
Li, Yuhao
Rong, Xianglu
Um, Irene S. I.
Yamahara, Johji
Wang, Jianwei
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-28
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
PPARs play a pivotal role in regulating lipid and glucose homeostasis and are involved in diverse biological activities in skin.
Pomegranate flower (PGF, an antidiabetic therapy in Unani and Ayurvedic medicines) has been previously demonstrated to activate both PPARalpha/gamma.
Here, we found that treatment of mice with the diet containing PGF powder over 55 weeks attenuated ageing-induced abnormal increases in the homeostasis model assessment of insulin resistance, glucose concentrations during oral glucose tolerance test, and adipose insulin resistance index.
The diet tended to decrease the excessive peri-ovary fat mass.
It, however, increased the thinned subcutaneous fat thickness.
In addition, the diet restored decreases in skin water content, epidermis thickness, and collagen density in corium.
Thus, our results demonstrate that long-term treatment with the Unani and Ayurvedic therapy ameliorates ageing-induced insulin resistance, which is associated with reversal of ageing-induced fat redistribution.
Further, PGF attenuates ageing-mediated undesirable skin abnormalities.
American Psychological Association (APA)
Wang, Jianwei& Rong, Xianglu& Um, Irene S. I.& Yamahara, Johji& Li, Yuhao. 2011. 55-Week Treatment of Mice with the Unani and Ayurvedic Medicine Pomegranate Flower Ameliorates Ageing-Associated Insulin Resistance and Skin Abnormalities. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028263
Modern Language Association (MLA)
Wang, Jianwei…[et al.]. 55-Week Treatment of Mice with the Unani and Ayurvedic Medicine Pomegranate Flower Ameliorates Ageing-Associated Insulin Resistance and Skin Abnormalities. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028263
American Medical Association (AMA)
Wang, Jianwei& Rong, Xianglu& Um, Irene S. I.& Yamahara, Johji& Li, Yuhao. 55-Week Treatment of Mice with the Unani and Ayurvedic Medicine Pomegranate Flower Ameliorates Ageing-Associated Insulin Resistance and Skin Abnormalities. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028263
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028263