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Effects of Bee Venom on Glutamate-Induced Toxicity in Neuronal and Glial Cells
Joint Authors
Lee, Sang Min
Kim, Seon Hwy
Baek, Myung Gi
Jiang, Jing Hua
Choi, Sun-Mi
Yang, Eun Jin
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-23
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Bee venom (BV), which is extracted from honeybees, is used in traditional Korean medical therapy.
Several groups have demonstrated the anti-inflammatory effects of BV in osteoarthritis both in vivo and in vitro.
Glutamate is the predominant excitatory neurotransmitter in the central nervous system (CNS).
Changes in glutamate release and uptake due to alterations in the activity of glutamate transporters have been reported in many neurodegenerative diseases, including Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis.
To assess if BV can prevent glutamate-mediated neurotoxicity, we examined cell viability and signal transduction in glutamate-treated neuronal and microglial cells in the presence and absence of BV.
We induced glutamatergic toxicity in neuronal cells and microglial cells and found that BV protected against cell death.
Furthermore, BV significantly inhibited the cellular toxicity of glutamate, and pretreatment with BV altered MAP kinase activation (e.g., JNK, ERK, and p38) following exposure to glutamate.
These findings suggest that treatment with BV may be helpful in reducing glutamatergic cell toxicity in neurodegenerative diseases.
American Psychological Association (APA)
Lee, Sang Min& Yang, Eun Jin& Choi, Sun-Mi& Kim, Seon Hwy& Baek, Myung Gi& Jiang, Jing Hua. 2011. Effects of Bee Venom on Glutamate-Induced Toxicity in Neuronal and Glial Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028274
Modern Language Association (MLA)
Lee, Sang Min…[et al.]. Effects of Bee Venom on Glutamate-Induced Toxicity in Neuronal and Glial Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028274
American Medical Association (AMA)
Lee, Sang Min& Yang, Eun Jin& Choi, Sun-Mi& Kim, Seon Hwy& Baek, Myung Gi& Jiang, Jing Hua. Effects of Bee Venom on Glutamate-Induced Toxicity in Neuronal and Glial Cells. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028274
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028274