Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases
Joint Authors
Cao, Yunfeng
Huang, Ting
Cao, Jun
Chen, Jian-Xing
Liu, Yong
He, Rong-Rong
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-16
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Icariin is known as an indicative constituent of the Epimedium genus, which has been commonly used in Chinese herbal medicine to enhance treat impotence and improve sexual function, as well as for several other indications for over 2000 years.
In this study, we aimed to investigate the effects of icariin and its intestinal metabolites on the activities of human UDP-glucuronosyltransferase (UGT) activities.
Using a panel of recombinant human UGT isoforms, we found that icariin exhibited potent inhibition against UGT1A3.
It is interesting that the intestinal metabolites of icariin exhibited a different inhibition profile compared with icariin.
Different from icariin, icariside II was a potent inhibitor of UGT1A4, UGT1A7, UGT1A9, and UGT2B7, and icaritin was a potent inhibitor of UGT1A7 and UGT1A9.
The potential for drug interactions in vivo was also quantitatively predicted and compared.
The quantitative prediction of risks indicated that in vivo inhibition against intestinal UGT1A3, UGT1A4, and UGT1A7 would likely occur after oral administration of icariin products.
American Psychological Association (APA)
Cao, Yunfeng& He, Rong-Rong& Cao, Jun& Chen, Jian-Xing& Huang, Ting& Liu, Yong. 2012. Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028287
Modern Language Association (MLA)
Cao, Yunfeng…[et al.]. Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028287
American Medical Association (AMA)
Cao, Yunfeng& He, Rong-Rong& Cao, Jun& Chen, Jian-Xing& Huang, Ting& Liu, Yong. Drug-Drug Interactions Potential of Icariin and Its Intestinal Metabolites via Inhibition of Intestinal UDP-Glucuronosyltransferases. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028287
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028287