Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway
Joint Authors
Tang, Sai-Wen
Lee, Shoei-Sheng
Lin, Jung-Yaw
Wang, Shih-Chin
Lam, Sio-Hong
Wang, Chung-Chieh
Liu, Yu-Huei
Lin, Hsuan-Yuan
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-08
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Renal cell carcinoma (RCC) cells are characterized by strong drug resistance and high metastatic incidence.
In this study, the effects of ten kinds of Chinese herbs on RCC cell migration and proliferation were examined.
Aqueous extract of Paeonia suffruticosa (PS-A) exerted strong inhibitory effects on cancer cell migration, mobility, and invasion.
The results of mouse xenograft experiments showed that the treatment of PS-A significantly suppressed tumor growth and pulmonary metastasis.
We further found that PS-A markedly decreased expression of VEGF receptor-3 (VEGFR-3) and phosphorylation of FAK in RCC cells.
Moreover, the activation of Rac-1, a modulator of cytoskeletal dynamics, was remarkably reduced by PS-A.
Additionally, PS-A suppressed polymerization of actin filament as demonstrated by confocal microscopy analysis and decreased the ratio of F-actin to G-actin in RCC cells, suggesting that PS-A inhibits RCC cell migration through modulating VEGFR-3/FAK/Rac-1 pathway to disrupt actin filament polymerization.
In conclusion, this research elucidates the effects and molecular mechanism for antimigration of PS-A on RCC cells and suggests PS-A to be a therapeutic or adjuvant strategy for the patients with aggressive RCC.
American Psychological Association (APA)
Wang, Shih-Chin& Tang, Sai-Wen& Lam, Sio-Hong& Wang, Chung-Chieh& Liu, Yu-Huei& Lin, Hsuan-Yuan…[et al.]. 2012. Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028296
Modern Language Association (MLA)
Wang, Shih-Chin…[et al.]. Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028296
American Medical Association (AMA)
Wang, Shih-Chin& Tang, Sai-Wen& Lam, Sio-Hong& Wang, Chung-Chieh& Liu, Yu-Huei& Lin, Hsuan-Yuan…[et al.]. Aqueous Extract of Paeonia suffruticosa Inhibits Migration and Metastasis of Renal Cell Carcinoma Cells via Suppressing VEGFR-3 Pathway. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028296
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028296