Ixora parviflora Protects against UVB-Induced Photoaging by Inhibiting the Expression of MMPs, MAP Kinases, and COX-2 and by Promoting Type I Procollagen Synthesis
Joint Authors
Shih, I-Chen
Fan, Pei-Ching
Tsai, Shang-Yuan
Chiang, Hsiu-Mei
Wen, Kuo-Ching
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-11, 11 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-12-01
Country of Publication
Egypt
No. of Pages
11
Main Subjects
Abstract EN
Ixora parviflora with high polyphenol content exhibited antioxidant activity and reducing UVB-induced intracellular reactive oxygen species production.
In this study, results of the photoaging screening experiments revealed that IPE at 1000 μg/mL reduced the activity of bacterial collagenase by 92.7 ± 4.2% and reduced the activity of elastase by 32.6 ± 1.4%.
Therefore, we investigated the mechanisms by which IPE exerts its anti-photoaging activity.
IPE at 1 μg/mL led to an increase in type I procollagen expression and increased total collagen synthesis in fibroblasts at 5 μg/mL.
We found that IPE inhibited MMP-1, MMP-3, and MMP-9 expression at doses of 1, 5, and 10 μg/mL, respectively, in fibroblasts exposed to UV irradiation (40 mJ/cm2).
Gelatin zymography assay showed that IPE at 50 μg/mL inhibited MMP-9 secretion/activity in cultured fibroblasts after UVB exposure.
In addition, IPE inhibited the phosphorylation of p38, ERK, and JNK induced by UVB.
Furthermore, IPE inhibited the UVB-induced expression of Smad7.
In addition, IPE at 1 μg/mL inhibited NO production and COX-2 expression in UV-exposed fibroblasts.
These findings show that IPE exhibits anti-inflammatory and anti-photoaging activities, indicating that IPE could be a potential anti-aging agent.
American Psychological Association (APA)
Wen, Kuo-Ching& Fan, Pei-Ching& Tsai, Shang-Yuan& Shih, I-Chen& Chiang, Hsiu-Mei. 2011. Ixora parviflora Protects against UVB-Induced Photoaging by Inhibiting the Expression of MMPs, MAP Kinases, and COX-2 and by Promoting Type I Procollagen Synthesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028302
Modern Language Association (MLA)
Wen, Kuo-Ching…[et al.]. Ixora parviflora Protects against UVB-Induced Photoaging by Inhibiting the Expression of MMPs, MAP Kinases, and COX-2 and by Promoting Type I Procollagen Synthesis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-11.
https://search.emarefa.net/detail/BIM-1028302
American Medical Association (AMA)
Wen, Kuo-Ching& Fan, Pei-Ching& Tsai, Shang-Yuan& Shih, I-Chen& Chiang, Hsiu-Mei. Ixora parviflora Protects against UVB-Induced Photoaging by Inhibiting the Expression of MMPs, MAP Kinases, and COX-2 and by Promoting Type I Procollagen Synthesis. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-11.
https://search.emarefa.net/detail/BIM-1028302
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028302