Furanodiene Induces Endoplasmic Reticulum Stress and Presents Antiproliferative Activities in Lung Cancer Cells
Joint Authors
Wang, Yi-Tao
Xu, Wen-Shan
Dang, Yuan-Ye
Guo, Jia-Jie
Lu, Jin-Jian
Chen, Xiu-Ping
Wu, Guo-Sheng
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-08
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Furanodiene (FUR) is a natural terpenoid isolated from Curcumae Rhizoma, a well-known Chinese medicinal herb that presents antiproliferation activities in several cancer cell lines.
In this study, we demonstrated that FUR concentration dependently inhibits the cell proliferation of A549, NIH-H1299, and 95-D lung cancer cells.
β-elemene, another terpenoid isolated from Curcumae Rhizoma, exhibited weaker antiproliferative effects in A549 and NIH-H1299 cells and activities similar to FUR in 95-D cells.
FUR significantly inhibited colony formation in A549 and 95-D cells and upregulated both the mRNA and protein expression levels of binding immunoglobulin protein (BIP) and C/EBP homologous protein (CHOP), indicating that endoplasmic reticulum (ER) stress is induced.
FUR treatment led to the accumulation of CHOP in the nucleus, which further confirms induction of ER stress.
Furthermore, combined treatment of FUR with paclitaxel showed significant synergetic activities in NIH-H1299 and 95-D cells, suggesting its potential roles in combination therapy.
These findings provide a basis for the further study of the anticancer effects in vivo and the internal mechanisms of FUR.
American Psychological Association (APA)
Xu, Wen-Shan& Dang, Yuan-Ye& Guo, Jia-Jie& Wu, Guo-Sheng& Lu, Jin-Jian& Chen, Xiu-Ping…[et al.]. 2012. Furanodiene Induces Endoplasmic Reticulum Stress and Presents Antiproliferative Activities in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028307
Modern Language Association (MLA)
Xu, Wen-Shan…[et al.]. Furanodiene Induces Endoplasmic Reticulum Stress and Presents Antiproliferative Activities in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028307
American Medical Association (AMA)
Xu, Wen-Shan& Dang, Yuan-Ye& Guo, Jia-Jie& Wu, Guo-Sheng& Lu, Jin-Jian& Chen, Xiu-Ping…[et al.]. Furanodiene Induces Endoplasmic Reticulum Stress and Presents Antiproliferative Activities in Lung Cancer Cells. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028307
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028307