Total Saponin from Root of Actinidia valvata Dunn Inhibits Hepatoma 22 Growth and Metastasis In Vivo by Suppression Angiogenesis
Joint Authors
Xin, Hailiang
Zheng, Guoyin
Ling, Chang-Quan
Xu, Yan-Fen
Li, Bai
Zhai, Xiao-Feng
Zhang, Yuan-Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-08-22
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
The root of Actinidia valvata dunn has been widely used in the treatment of hepatocellular carcinoma (HCC), proved to be beneficial for a longer and better life in China.
In present work, total saponin from root of Actinidia valvata Dunn (TSAVD) was extracted, and its effects on hepatoma H22-based mouse in vivo were observed.
Primarily transplanted hypodermal hepatoma H22-based mice were used to observe TSAVD effect on tumor growth.
The microvessel density (MVD), vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF) are characterized factors of angiogenesis, which were compared between TSAVD-treated and control groups.
Antimetastasis effect on experimental pulmonary metastasis hepatoma mice was also observed in the study.
The results demonstrated that TSAVD can effectively inhibit HCC growth and metastasis in vivo, inhibit the formation of microvessel, downregulate expressions of VEGF and bFGF, and retrain angiogenesis of hepatoma 22 which could be one of the reasons.
American Psychological Association (APA)
Zheng, Guoyin& Xin, Hailiang& Xu, Yan-Fen& Li, Bai& Zhai, Xiao-Feng& Zhang, Yuan-Hui…[et al.]. 2012. Total Saponin from Root of Actinidia valvata Dunn Inhibits Hepatoma 22 Growth and Metastasis In Vivo by Suppression Angiogenesis. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028313
Modern Language Association (MLA)
Zheng, Guoyin…[et al.]. Total Saponin from Root of Actinidia valvata Dunn Inhibits Hepatoma 22 Growth and Metastasis In Vivo by Suppression Angiogenesis. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028313
American Medical Association (AMA)
Zheng, Guoyin& Xin, Hailiang& Xu, Yan-Fen& Li, Bai& Zhai, Xiao-Feng& Zhang, Yuan-Hui…[et al.]. Total Saponin from Root of Actinidia valvata Dunn Inhibits Hepatoma 22 Growth and Metastasis In Vivo by Suppression Angiogenesis. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028313
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028313