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Ethanolic Extract of Vitis thunbergii Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits
Joint Authors
Pan, Chun-Hsu
Tsai, Chia-Hua
Lin, Wen-Hsin
Chen, Guo-Yan
Wu, Chieh-Hsi
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-03-28
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Vitis thunbergii (VT) is a wild grape that has been shown to provide various cardioprotective effects.
The present study was designed to examine whether a VT extract could reduce serum lipid levels and prevent atherogenesis in a hypercholesterolemic rabbit model.
At the end of an 8-week study, our results showed that a VT extract supplement markedly suppressed the serum levels of cholesterol and low-density lipoprotein, reduced lipid accumulation in liver tissues, and limited aortic fatty streaks.
Our findings suggest that the VT extract activated AMPK (5′-adenosine monophosphate-activated protein kinase) with subsequent inhibition of the activation of ACC (acetyl-CoA carboxylase).
Our results suggest that this VT extract could be further developed as a potential lipid-lowering agent and as a natural health food to prevent atherogenesis.
American Psychological Association (APA)
Pan, Chun-Hsu& Tsai, Chia-Hua& Lin, Wen-Hsin& Chen, Guo-Yan& Wu, Chieh-Hsi. 2012. Ethanolic Extract of Vitis thunbergii Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028316
Modern Language Association (MLA)
Pan, Chun-Hsu…[et al.]. Ethanolic Extract of Vitis thunbergii Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028316
American Medical Association (AMA)
Pan, Chun-Hsu& Tsai, Chia-Hua& Lin, Wen-Hsin& Chen, Guo-Yan& Wu, Chieh-Hsi. Ethanolic Extract of Vitis thunbergii Exhibits Lipid Lowering Properties via Modulation of the AMPK-ACC Pathway in Hypercholesterolemic Rabbits. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028316
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028316