Correlation between Chemical Composition of Curcuma domestica and Curcuma xanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation
Joint Authors
Jantan, Ibrahim
Saputri, Fadlina Chany
Qaisar, Muhammad Naeem
Buang, Fhataheya
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-26
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
The antioxidant activity of the curcuminoids of Curcuma domestica L.
and C.
xanthorrhiza Roxb.
and eight compounds which are prevalent constituents of their rhizome oils were investigated in an effort to correlate human low-density lipoprotein (LDL) antioxidant activity with the effect of the herbs and their components.
The antioxidant activity was examined using thiobarbituric acid reactive substances (TBARSs) assay with human LDL as the oxidation substrate.
The methanol extracts and rhizome oils of C.
xanthorrhiza and C.
domestica showed strong inhibitory activity on copper-mediated oxidation of LDL.
Curcumin, demethoxycurcumin, and bisdemethoxycurcumin, isolated from the methanol extracts of both plants, exhibited stronger activity than probucol (IC50 value 0.57 μmol/L) as reference, with IC50 values ranging from 0.15 to 0.33 μmol/L.
Xanthorrhizol, the most abundant component (31.9%) of the oil of C.
xanthorrhiza, showed relatively strong activity with an IC50 value of 1.93 μmol/L.
The major components of C.
domestica, ar-turmerone (45.8%) and zerumbone (3.5%), exhibited IC50 values of 10.18 and 24.90 μmol/L, respectively.
The high levels of curcuminoids in the methanol extracts and xanthorrhizol, ar-turmerone and zerumbone in the oils, and in combination with the minor components were responsible for the high LDL antioxidant activity of the herbs.
American Psychological Association (APA)
Jantan, Ibrahim& Saputri, Fadlina Chany& Qaisar, Muhammad Naeem& Buang, Fhataheya. 2012. Correlation between Chemical Composition of Curcuma domestica and Curcuma xanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028318
Modern Language Association (MLA)
Jantan, Ibrahim…[et al.]. Correlation between Chemical Composition of Curcuma domestica and Curcuma xanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028318
American Medical Association (AMA)
Jantan, Ibrahim& Saputri, Fadlina Chany& Qaisar, Muhammad Naeem& Buang, Fhataheya. Correlation between Chemical Composition of Curcuma domestica and Curcuma xanthorrhiza and Their Antioxidant Effect on Human Low-Density Lipoprotein Oxidation. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028318
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028318