Bojesodok-eum, a Herbal Prescription, Ameliorates Acute Inflammation in Association with the Inhibition of NF-κB-Mediated Nitric Oxide and ProInflammatory Cytokine Production
Joint Authors
Jo, Mi Jeong
Jee, Seon Young
Sohn, Kook Ho
Cho, Won Joon
Lee, Jong Rok
Kim, Sang Chan
Kim, Young Woo
Cho, Il Je
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-08
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Bojesodok-eum (BSE) is a herbal prescription consisting of Coptidis Rhizoma and Scutellariae Radix as main components.
This paper investigated the effects of BSE on the induction of nitric oxide (NO), prostaglandin E2 (PGE2), and proinflammatory cytokines that are caused by lipopolysaccharide (LPS) in murine macrophage cell line and on the paw edema formation in animals.
Administration of BSE (0.3 g/kg and 1 g/kg) in rats significantly inhibited carrageenan-induced paw edema formation, as did dexamethasone, an anti-inflammatory positive control drug.
In cell model, treatment of BSE decreased the production of NO and PGE2 in RAW264.7 cells stimulated by LPS.
BSE also inhibited the expression of iNOS and COX-2 protein as well as COX activity in a concentration-dependent manner.
Consistently, BSE suppressed the ability of LPS to produce TNF-α, interleukin-1β, and interleukin-6.
LPS treatment induced nuclear NF-κB level and I-κBα phosphorylation, which were inhibited subsequent treatment of BSE, suggesting its repression of LPS-inducible NF-κB activation.
BSE abrogated the induction of NO, PGE2, and proinflammatory cytokines, as well as iNOS and COX-2 protein expression in RAW264.7 cells stimulated by LPS as mediated with NF-κB inhibition.
American Psychological Association (APA)
Sohn, Kook Ho& Jo, Mi Jeong& Cho, Won Joon& Lee, Jong Rok& Cho, Il Je& Kim, Sang Chan…[et al.]. 2012. Bojesodok-eum, a Herbal Prescription, Ameliorates Acute Inflammation in Association with the Inhibition of NF-κB-Mediated Nitric Oxide and ProInflammatory Cytokine Production. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028322
Modern Language Association (MLA)
Sohn, Kook Ho…[et al.]. Bojesodok-eum, a Herbal Prescription, Ameliorates Acute Inflammation in Association with the Inhibition of NF-κB-Mediated Nitric Oxide and ProInflammatory Cytokine Production. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028322
American Medical Association (AMA)
Sohn, Kook Ho& Jo, Mi Jeong& Cho, Won Joon& Lee, Jong Rok& Cho, Il Je& Kim, Sang Chan…[et al.]. Bojesodok-eum, a Herbal Prescription, Ameliorates Acute Inflammation in Association with the Inhibition of NF-κB-Mediated Nitric Oxide and ProInflammatory Cytokine Production. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028322
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028322