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Neuroprotective Activity of Sibjeondaebo-tang on Aβ Peptide-Induced Damages
Joint Authors
Lim, Junghwa
Yim, Hyeon Ju
Kim, Min Hee
Namgung, Uk
Lee, Sang Ryong
Jung, In Chul
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-8, 8 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-15
Country of Publication
Egypt
No. of Pages
8
Main Subjects
Abstract EN
Background.
Sibjeondaebo-tang (SJDBT) has been used to treat diverse disorders including neuropsychiatric disabilities in traditional Korean medicine.
Objective.
The present study aims to investigate the potential effects of SJDBT on neuroprotection against Aβ peptide-induced damage using in vitro culture and in vivo rat brain systems.
Materials and Methods.
PC12 cell viability was analyzed by MTT assay, and neurite arborizations and caspase 3 protein signals in cultured PC12 cells and in vivo cortical neurons were analyzed by immunofluorescence staining.
Phospho-Erk1/2 protein was analyzed by immunofluorescence staining and western blot analysis.
Results.
In PC12 cells, atrophied cell body and reduced neurite extension by Aβ treatment were recovered by SJDBT treatment.
Caspase 3 protein signals were increased in Aβ-treated PC12 cells, but SJDBT treatment decreased apoptotic cell death.
Caspase 3 activation in cortical neurons, which was induced similarly by Aβ treatment, was reduced by SJDBT treatment.
Furthermore, phospho-Erk1/2 protein levels, which had been decreased by Aβ treatment, were elevated in the cortical neurons by SJDBT treatment.
Conclusion.
These data show that SJDBT may play a role in protecting from damages induced by Aβ in neuronal tissue and further suggest that SJDBT can be explored as the potential therapeutic target for AD treatments in human.
American Psychological Association (APA)
Yim, Hyeon Ju& Lim, Junghwa& Kim, Min Hee& Namgung, Uk& Lee, Sang Ryong& Jung, In Chul. 2012. Neuroprotective Activity of Sibjeondaebo-tang on Aβ Peptide-Induced Damages. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028323
Modern Language Association (MLA)
Yim, Hyeon Ju…[et al.]. Neuroprotective Activity of Sibjeondaebo-tang on Aβ Peptide-Induced Damages. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-8.
https://search.emarefa.net/detail/BIM-1028323
American Medical Association (AMA)
Yim, Hyeon Ju& Lim, Junghwa& Kim, Min Hee& Namgung, Uk& Lee, Sang Ryong& Jung, In Chul. Neuroprotective Activity of Sibjeondaebo-tang on Aβ Peptide-Induced Damages. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-8.
https://search.emarefa.net/detail/BIM-1028323
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028323