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The Immunomodulatory Effect of You-Gui-Wan on Dermatogoides-pteronyssinus-Induced Asthma
Joint Authors
Chao, Yun-Peng
Lin, Chin-Che
Wang, Shulhn-Der
Kao, Shung-Te
Lin, Li-Jen
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-05-20
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The traditional Chinese medicine You-Gui-Wan (YGW) contains ten species of medicinal plants and has been used to improve health in remissive states of asthma for hundreds of years in Asia.
However, little is known about the immunomodulatory mechanisms in vivo.
Therefore, this study investigated the pathologic and immunologic responses to YGW in mice that had been repeatedly exposed to Dermatogoides-pteronyssinus (Der p).
YGW reduced Der-p-induced airway hyperresponsiveness and total IgE in serum.
It also inhibited eosinophil infiltration by downregulating the protein expression of IL-5 in serum and changed the Th2-bios in BALF by upregulating IL-12.
Results of the collagen assay and histopathologic examination showed that YGW reduced airway remodeling in the lung.
In addition, after YGW treatment there was a relative decrease in mRNA expression of TGF-β1, IL-13, eotaxin, RANTES, and MCP-1 in lung in the YGW group.
The results of EMSA and immunohistochemistry revealed that YGW inhibited NF-κB expression in epithelial lung cells.
YGW exerts its regulative effects in chronic allergic asthmatic mice via its anti-inflammatory activity and by inhibiting the progression of airway remodeling.
American Psychological Association (APA)
Lin, Li-Jen& Lin, Chin-Che& Wang, Shulhn-Der& Chao, Yun-Peng& Kao, Shung-Te. 2012. The Immunomodulatory Effect of You-Gui-Wan on Dermatogoides-pteronyssinus-Induced Asthma. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028334
Modern Language Association (MLA)
Lin, Chin-Che…[et al.]. The Immunomodulatory Effect of You-Gui-Wan on Dermatogoides-pteronyssinus-Induced Asthma. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028334
American Medical Association (AMA)
Lin, Li-Jen& Lin, Chin-Che& Wang, Shulhn-Der& Chao, Yun-Peng& Kao, Shung-Te. The Immunomodulatory Effect of You-Gui-Wan on Dermatogoides-pteronyssinus-Induced Asthma. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028334
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028334