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Effects of Electroacupuncture of Different Frequencies on the Release Profile of Endogenous Opioid Peptides in the Central Nerve System of Goats
Joint Authors
Cheng, Li-Li
Wang, Qiong
Xiong, Cheng
Zhou, Min-Yan
Qiu, Zheng-Ying
Ding, Ming-Xing
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-24
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
To investigate the release profile of met-enkephalin, β-endorphin, and dynorphin-A in ruminants’ CNS, goats were stimulated by electroacupuncture of 0, 2, 40, 60, 80, or 100 Hz for 30 min.
The pain threshold was measured using potassium iontophoresis.
The peptide levels were determined with SABC immunohistochemisty.
The results showed that 60 Hz increased pain threshold by 91%; its increasing rate was higher (P<0.01) than any other frequency did.
2 Hz and 100 Hz increased met-enkephalin immunoactivities (P<0.05) in nucleus accumbens, septal area, caudate nucleus, amygdala, paraventricular nucleus of hypothalamus, periaqueductal gray, dorsal raphe nucleus, and locus ceruleus.
The two frequencies elicited β-endorphin release (P<0.05) in nucleus accumbens, septal area, supraoptic nucleus, ventromedial nucleus of hypothalamus, periaqueductal gray, dorsal raphe nucleus, locus ceruleus, solitary nucleus and amygdala.
60 Hz increased (P<0.05) met-enkephalin or β-endorphin immunoactivities in the nuclei and areas mentioned above, and habenular nucleus, substantia nigra, parabrachial nucleus, and nucleus raphe magnus.
High frequencies increased dynorphin-A release (P<0.05) in spinal cord dorsal horn and most analgesia-related nuclei.
It suggested that 60 Hz induced the simultaneous release of the three peptides in extensive analgesia-related nuclei and areas of the CNS, which may be contributive to optimal analgesic effects and species variation.
American Psychological Association (APA)
Cheng, Li-Li& Ding, Ming-Xing& Xiong, Cheng& Zhou, Min-Yan& Qiu, Zheng-Ying& Wang, Qiong. 2012. Effects of Electroacupuncture of Different Frequencies on the Release Profile of Endogenous Opioid Peptides in the Central Nerve System of Goats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028335
Modern Language Association (MLA)
Cheng, Li-Li…[et al.]. Effects of Electroacupuncture of Different Frequencies on the Release Profile of Endogenous Opioid Peptides in the Central Nerve System of Goats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028335
American Medical Association (AMA)
Cheng, Li-Li& Ding, Ming-Xing& Xiong, Cheng& Zhou, Min-Yan& Qiu, Zheng-Ying& Wang, Qiong. Effects of Electroacupuncture of Different Frequencies on the Release Profile of Endogenous Opioid Peptides in the Central Nerve System of Goats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028335
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028335