Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9
Joint Authors
Sheu, Ming-Jyh
Liao, Jung-Chun
Deng, Jeng-Shyan
Hsieh, Wen-Tsong
Wu, Chieh-Hsi
Huang, Guan-Jhong
Chiu, Chuan-Sung
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-10-15
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
The hepatoprotective potential of hispolon against carbon tetrachloride (CCl4)-induced liver damage was evaluated in preventive models in rats.
Male rats were intraperitoneally treated with hispolon or silymarin once daily for 7 consecutive days.
One hour after the final hispolon or silymarin treatment, the rats were injected with CCl4.
Administration with hispolon or silymarin significantly decreased the alanine aminotransferase (ALT) and aspartate aminotransferase (AST) levels in serum and increased the activities of superoxide dismutase (SOD), catalase, glutathione peroxidase (GPx), and glutathione (GSH) content and decreased the malondialdehyde (MDA) content in liver compared with CCl4-treated group.
Liver histopathology also showed that hispolon reduced the incidence of liver lesions induced by CCl4.
In addition, hispolon decreased nitric oxide (NO) production and tumor necrosis factor (TNF-α), inducible NO synthase (iNOS) and cyclooxygenase-2 (COX-2) activation in CCl4-treated rats.
We also examined the involvement of matrix metalloproteinase (MMP)-9 in the development of CCl4-induced liver damage in rats.
Hispolon inhibited the expression of MMP-9 protein, indicating that MMP-9 played an important role in the development of CCl4-induced rat liver damage.
Therefore, we speculate that hispolon protects rats from liver damage through their prophylactic redox balancing ability and anti-inflammation capacity.
American Psychological Association (APA)
Huang, Guan-Jhong& Deng, Jeng-Shyan& Chiu, Chuan-Sung& Liao, Jung-Chun& Hsieh, Wen-Tsong& Sheu, Ming-Jyh…[et al.]. 2011. Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028338
Modern Language Association (MLA)
Huang, Guan-Jhong…[et al.]. Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028338
American Medical Association (AMA)
Huang, Guan-Jhong& Deng, Jeng-Shyan& Chiu, Chuan-Sung& Liao, Jung-Chun& Hsieh, Wen-Tsong& Sheu, Ming-Jyh…[et al.]. Hispolon Protects against Acute Liver Damage in the Rat by Inhibiting Lipid Peroxidation, Proinflammatory Cytokine, and Oxidative Stress and Downregulating the Expressions of iNOS, COX-2, and MMP-9. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028338
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028338