Effect of the Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on the Prevention of an Allergic Airway Response in Mice
Joint Authors
Chen, Kun-Nan
Chen, Yen-Po
Dai, Ting-Yeu
Kuo, Ching-Yun
Wang, Ting
Wang, Chih-Hua
Chen, Ming-Ju
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-10, 10 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-12-23
Country of Publication
Egypt
No. of Pages
10
Main Subjects
Abstract EN
Two mouse models were used to assay the antiallergic effects of the velvet antler (VA) of Formosan sambar deer (Cervus unicolor swinhoei) in this study.
The results using the ovalbumin- (OVA-) sensitized mouse model showed that the levels of total IgE and OVA-specific IgE were reduced after VA powder was administrated for 4 weeks.
In addition, the ex vivo results indicated that the secretion of T helper cell 1 (Th1), regulatory T (Treg), and Th17 cytokines by splenocytes was significantly increased (P<0.05) when VA powder was administered to the mice.
Furthermore, OVA-allergic asthma mice that have been orally administrated with VA powder showed a strong inhibition of Th2 cytokine and proinflammatory cytokine production in bronchoalveolar fluid compared to control mice.
An increase in the regulatory T-cell population of splenocytes in the allergic asthma mice after oral administration of VA was also observed.
All the features of the asthmatic phenotype, including airway inflammation and the development of airway hyperresponsiveness, were reduced by treatment with VA.
These findings support the hypothesis that oral feeding of VA may be an effective way of alleviating asthmatic symptoms in humans.
American Psychological Association (APA)
Kuo, Ching-Yun& Wang, Ting& Dai, Ting-Yeu& Wang, Chih-Hua& Chen, Kun-Nan& Chen, Yen-Po…[et al.]. 2012. Effect of the Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on the Prevention of an Allergic Airway Response in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028341
Modern Language Association (MLA)
Kuo, Ching-Yun…[et al.]. Effect of the Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on the Prevention of an Allergic Airway Response in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-10.
https://search.emarefa.net/detail/BIM-1028341
American Medical Association (AMA)
Kuo, Ching-Yun& Wang, Ting& Dai, Ting-Yeu& Wang, Chih-Hua& Chen, Kun-Nan& Chen, Yen-Po…[et al.]. Effect of the Velvet Antler of Formosan Sambar Deer (Cervus unicolor swinhoei) on the Prevention of an Allergic Airway Response in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-10.
https://search.emarefa.net/detail/BIM-1028341
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028341