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Evaluation of Topical Tocopherol Cream on Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats
Joint Authors
Lin, Teoh Seong
Abd Latiff, Azian
Mazlan, Musalmah
Wan Ngah, Wan Zurinah
Abdul Hamid, Noor Aini
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-6, 6 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-10-14
Country of Publication
Egypt
No. of Pages
6
Main Subjects
Abstract EN
Diabetes is a common cause of delayed wound healing.
The aim of the study was to determine the effect of topical administration of tocopherol cream on the wound healing process in diabetic rats.
The study was conducted using 18 male Sprague Dawley rats which were divided into three groups: (I) diabetic rats receiving control cream (n=6), (II) diabetic rats receiving 0.06% tocopherol cream (n=6), and (III) diabetic rats receiving 0.29% tocopherol cream (n=6).
Four cutaneous wounds were created at the dorsal region of the rats.
Wound healing was assessed by total protein content, rate of wound closure estimation, and histological studies on the tenth day after wounding.
Tocopherol treatment enhanced the wound healing process by increasing rate of wound closure and total protein content significantly (P<0.05) compared to the control group.
Histological observation also showed better organized epithelium and more collagen fibers in the tocopherol treated groups.
Application of tocopherol cream enhances wound healing process in diabetic condition which is known to cause delay in wound healing.
American Psychological Association (APA)
Lin, Teoh Seong& Abd Latiff, Azian& Abdul Hamid, Noor Aini& Wan Ngah, Wan Zurinah& Mazlan, Musalmah. 2012. Evaluation of Topical Tocopherol Cream on Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028351
Modern Language Association (MLA)
Lin, Teoh Seong…[et al.]. Evaluation of Topical Tocopherol Cream on Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-6.
https://search.emarefa.net/detail/BIM-1028351
American Medical Association (AMA)
Lin, Teoh Seong& Abd Latiff, Azian& Abdul Hamid, Noor Aini& Wan Ngah, Wan Zurinah& Mazlan, Musalmah. Evaluation of Topical Tocopherol Cream on Cutaneous Wound Healing in Streptozotocin-Induced Diabetic Rats. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-6.
https://search.emarefa.net/detail/BIM-1028351
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028351