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Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo
Joint Authors
Wu, Justin C. Y.
Sung, Joseph J. Y.
Yang, Zhonghan
Grinchuk, Viktoriya
Che, Chun-Tao
Shea-Donohue, Terez
Zhao, Aiping
Ip, Paul Siu-Po
Berman, Brian
Lao, Lixing
Fong, Harry H. S.
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-02-22
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
Irritable bowel syndrome (IBS) is a functional bowel disorder and the etiology is not well understood.
Currently there is no cure for IBS and no existing medication induces symptom relief in all patients.
IBS-20 is a 20-herb Chinese medicinal formula that offers beneficial effects in patients with IBS; however, the underlying mechanisms are largely unknown.
This study showed that IBS-20 potently inhibited LPS- or IFNΓ-stimulated expression of pro-inflammatory cytokines, as well as classically activated macrophage marker nitric oxide synthase 2.
Similarly, IBS-20 or the component herb Coptis chinensis decreased LPS-stimulated pro-inflammatory cytokine secretion from JAWS II dendritic cells.
IBS-20 or the component herbs also blocked or attenuated the IFNΓ-induced drop in transepithelial electric resistance, an index of permeability, in fully differentiated Caco-2 monolayer.
Finally, the up-regulation of key inflammatory cytokines in inflamed colon from TNBS-treated mice was suppressed significantly by orally administrated IBS-20, including IFNΓ and IL-12p40.
These data indicate that the anti-inflammatory activities of IBS-20 may contribute to the beneficial effects of the herbal extract in patients with IBS, providing a potential mechanism of action for IBS-20.
In addition, IBS-20 may be a potential therapeutic agent against other Th1-dominant gut pathologies such as inflammatory bowel disease.
American Psychological Association (APA)
Yang, Zhonghan& Grinchuk, Viktoriya& Ip, Paul Siu-Po& Che, Chun-Tao& Fong, Harry H. S.& Lao, Lixing…[et al.]. 2012. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028352
Modern Language Association (MLA)
Yang, Zhonghan…[et al.]. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028352
American Medical Association (AMA)
Yang, Zhonghan& Grinchuk, Viktoriya& Ip, Paul Siu-Po& Che, Chun-Tao& Fong, Harry H. S.& Lao, Lixing…[et al.]. Anti-Inflammatory Activities of a Chinese Herbal Formula IBS-20 In Vitro and In Vivo. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028352
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028352