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Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice
Joint Authors
Peng, Wen-Huang
Chang, Ching-Wen
Hsu, Lieh-Ching
Ko, Yu-Jen
Cheng, Hao-Yuan
Hsieh, Ming-Tsuen
Lin, Yu-Chin
Cheng, Ying-Hui
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-12, 12 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2012-04-09
Country of Publication
Egypt
No. of Pages
12
Main Subjects
Abstract EN
This study investigated the antidepressant activity of ethanolic extract of U.
lanosa Wallich var.
appendiculata Ridsd (ULEtOH) for two-weeks administrations by using FST and TST on mice.
In order to understand the probable mechanism of antidepressant-like activity of ULEtOH in FST and TST, the researchers measured the levels of monoamines and monoamine oxidase activities in mice brain, and combined the antidepressant drugs (fluoxetine, imipramine, maprotiline, clorgyline, bupropion and ketanserin).
Lastly, the researchers analyzed the content of RHY in the ULEtOH.
The results showed that ULEtOH exhibited antidepressant-like activity in FST and TST in mice.
ULEtOH increased the levels of 5-HT and 5-HIAA in cortex, striatum, hippocampus, and hypothalamus, the levels of NE and MHPG in cortex and hippocampus, the level of NE in striatum, and the level of DOPAC in striatum.
Two-week injection of IMI, CLO, FLU and KET enhanced the antidepressant-like activity of ULEtOH.
ULEtOH inhibited the activity of MAO-A.
The amount of RHY in ULEtOH was 17.12 mg/g extract.
Our findings support the view that ULEtOH exerts antidepressant-like activity.
The antidepressant-like mechanism of ULEtOH may be related to the increase in monoamines levels in the hippocampus, cortex, striatum, and hypothalamus of mice.
American Psychological Association (APA)
Hsu, Lieh-Ching& Ko, Yu-Jen& Cheng, Hao-Yuan& Chang, Ching-Wen& Lin, Yu-Chin& Cheng, Ying-Hui…[et al.]. 2012. Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028356
Modern Language Association (MLA)
Hsu, Lieh-Ching…[et al.]. Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-12.
https://search.emarefa.net/detail/BIM-1028356
American Medical Association (AMA)
Hsu, Lieh-Ching& Ko, Yu-Jen& Cheng, Hao-Yuan& Chang, Ching-Wen& Lin, Yu-Chin& Cheng, Ying-Hui…[et al.]. Antidepressant-Like Activity of the Ethanolic Extract from Uncaria lanosa Wallich var. appendiculata Ridsd in the Forced Swimming Test and in the Tail Suspension Test in Mice. Evidence-Based Complementary and Alternative Medicine. 2012. Vol. 2012, no. 2012, pp.1-12.
https://search.emarefa.net/detail/BIM-1028356
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028356