Depression, Comorbidities, and Prescriptions of Antidepressants in a German Network of GPs and Specialists with Subspecialisation in Anthroposophic Medicine: A Longitudinal Observational Study

Abstract EN

Background.

Depression is a major reason for counselling in primary care.

Our study aims at evaluating pharmacological treatment strategies among physicians specialised in anthroposophic medicine (AM).

Methods.

From 2004 to 2008, twenty-two German primary care AM-physicians participated in this prospective, multicentre observational study.

Multiple logistic regression was used to determine factors associated with a prescription of any antidepressant medication.

Results.

A total of 2444 patients with depression were included (mean age: 49.1 years (SD: 15.4); 77.3% female).

2645 prescriptions of antidepressants for 833 patients were reported.

Phytotherapeutic preparations from Hypericum perforatum were the most frequently prescribed antidepressants over all (44.6% of all antidepressants), followed by amitriptyline (16.1%).

The likelihood of receiving an antidepressant medication did not depend on comorbidity after controlling for age, gender, physician specialisation, and type of depression (adjusted OR (AOR)=1.01; CI: 0.81–1.26).

Patients who had cancer were significantly less likely to be prescribed an antidepressant medication than those who had no cancer (AOR=0.75; CI: 0.57–0.97).

Conclusion.

This study provides a comprehensive analysis of everyday practice for the treatment of depression in AM -physicians.

Further analysis regarding the occurrence of critical combinations is of high interest to health services research.