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Cardioprotective Effects of Salvianolic Acid A on Myocardial Ischemia-Reperfusion Injury In Vivo and In Vitro
Joint Authors
Fan, Huaying
Yang, Liu
Fu, Fenghua
Xu, Hui
Meng, Qinggang
Teng, Lirong
Yang, Mingyan
Zhang, Leiming
Zhang, Ziliang
Liu, Ke
Zhu, Haibo
Source
Evidence-Based Complementary and Alternative Medicine
Issue
Vol. 2012, Issue 2012 (31 Dec. 2012), pp.1-9, 9 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2011-06-25
Country of Publication
Egypt
No. of Pages
9
Main Subjects
Abstract EN
Salvianolic acid A (SAA), one of the major active components of Danshen that is a traditional Chinese medicine, has been reported to possess protective effect in cardiac diseases and antioxidative activity.
This study aims to investigate the cardioprotection of SAA in vivo and in vitro using the model of myocardial ischemia-reperfusion in rat and hydrogen peroxide (H2O2)-induced H9c2 rat cardiomyoblasts apoptosis.
It was found that SAA significantly limited infarct size of ischemic myocardium when given immediately prior to reperfusion.
SAA also significantly suppressed cellular injury and apoptotic cell death.
Additionally, the results of western blot and phospho-specific antibody microarray analysis showed that SAA could up-regulate Bcl-2 expression and increase the phosphorylation of proteins such as Akt, p42/p44 extracellular signal-related kinases (Erk1/2), and their related effectors.
The phosphorylation of those points was related to suppress apoptosis.
In summary, SAA possesses marked protective effect on myocardial ischemia-reperfusion injury, which is related to its ability to reduce myocardial cell apoptosis and damage induced by oxidative stress.
The protection is achieved via up-regulation of Bcl-2 expression and affecting protein phosphorylation.
These findings indicate that SAA may be of value in cardioprotection during myocardial ischemia-reperfusion injury, which provide pharmacological evidence for clinical application.
American Psychological Association (APA)
Fan, Huaying& Yang, Liu& Fu, Fenghua& Xu, Hui& Meng, Qinggang& Zhu, Haibo…[et al.]. 2011. Cardioprotective Effects of Salvianolic Acid A on Myocardial Ischemia-Reperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine،Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028367
Modern Language Association (MLA)
Fan, Huaying…[et al.]. Cardioprotective Effects of Salvianolic Acid A on Myocardial Ischemia-Reperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine No. 2012 (2012), pp.1-9.
https://search.emarefa.net/detail/BIM-1028367
American Medical Association (AMA)
Fan, Huaying& Yang, Liu& Fu, Fenghua& Xu, Hui& Meng, Qinggang& Zhu, Haibo…[et al.]. Cardioprotective Effects of Salvianolic Acid A on Myocardial Ischemia-Reperfusion Injury In Vivo and In Vitro. Evidence-Based Complementary and Alternative Medicine. 2011. Vol. 2012, no. 2012, pp.1-9.
https://search.emarefa.net/detail/BIM-1028367
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1028367